Mecanismos moleculares antioxidantes modulados pelo exercí­cio fí­sico

Autores

  • Camila Baumer Tromm UNESC

DOI:

https://doi.org/10.33233/rbfe.v11i2.3393

Resumo

A geração de espécies reativas de oxigênio (EROs) é um fenômeno biológico que ocorre durante a vida celular. Estes compostos podem ativar vias de sinalização envolvidas na regulação do crescimento, proliferação, diferenciação e apoptose. A presença contí­nua de pequenos estí­mulos induzidos pelo exercí­cio provoca elevações mí­nimas nas concentrações de espécies reativas de oxigênio, as quais são hábeis para induzir a expressão de enzimas antioxidantes e outros mecanismos de defesa. O NFκB e MAPK são duas grandes vias de sinalização que podem ser ativadas em resposta às EROs induzidas pelo exercí­cio, tanto agudo quanto crônico (treinamento). Embora o papel destes compostos sobre a ativação de enzimas antioxidantes venha sendo investigado, os mecanismos intrí­nsecos da adaptação antioxidante permanecem obscuros.

Palavras-chave: treinamento fí­sico, transdução de sinal, defesa antioxidante.

Biografia do Autor

Camila Baumer Tromm, UNESC

Laboratório de Fisiologia e Bioquí­mica do Exercí­cio, Programa de Pós Graduação em Ciências da Saúde, Universidade do Extremo Sul Catarinense, Criciúma/SC

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Publicado

2012-06-10

Edição

v. 11 n. 2 (2012): Fisiologia do Exercí­cio v11n2

Seção

Revisões

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Copyright (c) 2012 Camila Baumer Tromm

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