Influência da composição corporal durante a hospitalização sobre a função pulmonar e força da musculatura inspiratória em pacientes com COVID-19: estudo transversal
DOI:
https://doi.org/10.33233/fb.v24i1.5345Palavras-chave:
COVID-19, composição corporal, testes de função respiratóriaResumo
Introdução: Cerca de 31% dos pacientes hospitalizados com COVID-19 perdem mais de 5% de seu peso inicial, levando a fraqueza muscular. Portanto, a composição corporal tornou-se foco de investigação, para estimar comprometimento pulmonar, força da musculatura inspiratória e mortalidade. Objetivos: Investigar se a perda de peso e a composição corporal de pacientes internados com COVID-19 influenciam na função pulmonar e na força muscular inspiratória após alta hospitalar. Métodos: Estudo transversal. Pacientes adultos foram avaliados após internação por COVID-19. Os desfechos avaliados foram função pulmonar, pressão inspiratória máxima (Pimáx), composição corporal e mortalidade. As correlações entre as variáveis foram estimadas pelo Coeficiente de Correlação de Pearson. Resultados: A capacidade Vital Forçada (CVF) foi correlacionada com perda de peso, massa muscular esquelética, massa magra, perna esquerda e massa livre de gordura; o volume expiratório forçado no primeiro segundo (VEF1) correlacionou-se apenas com a perda de peso; e a Pimáx foi correlacionada com massa muscular esquelética, massa magra, perna esquerda, perna direita e massa livre de gordura. Conclusão: Observou-se correlação moderada entre CVF e as variáveis de composição corporal analisadas, exceto massa magra da perna esquerda; entre VEF1 e perda de peso; e entre Pimáx e as variáveis de composição corporal analisadas, exceto perda de peso.
Referências
Di Filippo L, De Lorenzo R, D'Amico M, Sofia V, Roveri L, Mele R, et al. COVID-19 is associated with clinically significant weight loss and risk of malnutrition, independent of hospitalisation: A post-hoc analysis of a prospective cohort study. Clin Nutr. 2021;40(4):2420-6. doi: 10.1016/j.clnu.2020.10.043
Gao M, Wang Q, Piernas C, Astbury NM, Jebb SA, Holmes MV, et al. Associations between body composition, fat distribution and metabolic consequences of excess adiposity with severe COVID-19 outcomes: observational study and Mendelian randomisation analysis. Int J Obes. 2022;46:943-950. doi: 10.1038/s41366-021-01054-3
Anker MS, Landmesser U, Haehling SV, Butler J, Coats AJS, Anker SD. Weight loss, malnutrition, and cachexia in COVID-19: facts and numbers. Journal of Cachexia, Sarcopenia and Muscle. 2021;12(1):9-13. doi: 10.1002/jcsm.12674
Albarrán-Sánchez A, Ramírez-Rentería C, Anda-Garay JC, Noyola-García ME, Alberti-Minutti P, Flores-Padilla G, et al. Differences in mortality rate among patients hospitalized with severe COVID-19 according to their body mass index. Obes Sci Pract. 2021;8(4):423-432. doi: 10.1002/osp4.584
Donnelly JP, Wang XQ, Iwashyna TJ, Prescott HC. Readmission and death after initial hospital discharge among patients with COVID-19 in a large multihospital system. JAMA. 2020;325(3):304-306. https://doi:10.1001/jama.2020.21465
Ballvé A, Llauradó A, Palasí A, Quintana M, Martínez-Sáez E, Laínez E, et al. Weakness as a complication of COVID-19 in critically ill patients: clinical features and prognostic factors in a case series. Rev Neurol. 2021;73(1):10-16. doi: 10.33588/rn.7301.2021042
Plaza M, Sevilla GGP. Respiratory muscle sequelae in young university students infected by coronavirus disease 2019: an observational study. Rev Assoc Med Bras. 2022;68(2):245-249. doi: 10.1590/1806-9282.20211040
Zhang S, Bai W, Yue J, Qin L, Zhang C, Xu S, et al. Eight months follow-up study on pulmonary function, lung radiographic, and related physiological characteristics in COVID-19 survivors. Scientific Reports. 2021;13854:1-13. doi: 10.1038/s41598-021-93191-y
Carod-Artal FJ. Post-COVID-19 syndrome: epidemiology, diagnostic criteria and pathogenic mechanisms involved. Rev Neurol. 2021;72(11):384-396. doi: 10.33588/rn.7211.2021230
Freuer D, Linseisen J, C. Meisinger. Impact of body composition on COVID-19 susceptibility and severity: A two-sample multivariable Mendelian randomization study. Metabolism. 2021;118:154732. doi: 10.1016/j.metabol.2021.154732
Polese J, Sant'Ana L, Moulaz IR, Lara IC, Bernardi JM, Lima MD, et al. Pulmonary function evaluation after hospital discharge of patients with severe COVID-19. Clinics. 2021;76:e2848. doi: 10.6061/clinics/2021/e2848
Morgenthau AS, Levin MA, Freeman R, Reich DL, Klang E. Moderate or severe impairment in pulmonary function is associated with mortality in sarcoidosis patients infected with SARS-CoV-2. Lung. 2020;198:771-775. doi: 10.1007/s00408-020-00392-9
Mancuzo EV, Marinho CC, Machado-Coelho GLL, Batista AP, Oliveira JF, Andrade BH, et al. Lung function of patients hospitalized with COVID-19 at 45 days after hospital discharge: first report of a prospective multicenter study in Brazil. J Bras Pneumol. 2021;47(6):e20210162. doi: 10.36416/1806-3756/e20210162
Thomas M, OJ Price, JH Hull. Pulmonary function and COVID-19. Physiol Curr Opin. 2021;21:29-35. doi: 10.1016/j.cophys.2021.03.005
Allard L, E Ouedraogo, Molleville J, Bihan H,Giroux-Leprieur B, Sutton A, et al. Malnutrition: percentage and association with prognosis in patients hospitalized for coronavirus disease 2019. Nutrients. 2020;12(12):E3679. doi: 10.3390/nu12123679
Pironi L, Sasdelli AS, Ravaioli F, Baracco B, Battaiola C, Bocedi G, et al. Malnutrition and nutritional therapy in patients with SARS-CoV-2 disease. Clin Nutr. 2021;40(3):1330-7. doi: 10.1016/j.clnu.2020.08.021
Elm EV, Altman DG, Egger M, Pocock SJ, Gøtzsche PC, Vandenbroucke JP, et al. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. J Clin Epidemiol. 2008;61(4):344-9. doi: 10.1016/j.jclinepi.2007.11.008
Miller MR, Hankinson J, Brusasco V, Burgos F, Casaburi R, Coates A, et al. Standardisation of spirometry. Eur Respir J. 2005;26(2):319-38. doi: 10.1183/09031936.05.00034805
Sociedade Brasileira de Pneumologia e Tisiologia. Diretrizes para Testes de Função Pulmonar. J Pneumol [Internet]. 2002 [cited 2023 Jan 13];28(Suppl 3):S1-S238. Available from : https://www.jornaldepneumologia.com.br/details-supp/45
American Thoracic Society/European Respiratory. ATS/ERS Statement on respiratory muscle testing. Am J Respir Crit Care Med. 2002;166(4):518-24. doi: 10.1164/rccm.166.4.518
Neder JA, Andreoni S, Lerario MC, Nery LE. Reference values for lung function tests. II. Maximal respiratory pressures and voluntary ventilation. Braz J Med Biol Res. 1999;32(6):719-27. doi: 10.1590/S0100-879X1999000600007
Thluiz RR, Magnanini MMF. The logic of sample determination in epidemiological research. Cad Health Collect [Internet]. 2000 [cited 2023 Jan 13];8(2):9-28. Available from: https://pesquisa.bvsalud.org/portal/resource/pt/lil-326604
Banerjee J, Canamar CP, Voyageur C, Tangpraphaphorn S, Lemus A, Jr CC, et al. Mortality and readmission rates among patients with COVID-19 after discharge from acute care setting with supplemental oxygen. JAMA. 2021;4(4):e213990. https://doi:10.1001/jamanetworkopen.2021.3990
Akoglu H. User's guide to correlation coefficients. Turk J Emerg Med. 2018;18(3):91–3. doi: 10.1016/j.tjem.2018.08.001
Ayres M, Ayres JR, Ayres DL, Santos AS. BioEstat 5.3: Statistical applications in the areas of Biological and Medical Sciences. Belém: Mamirauá Civil Society Publishing House; 2011. p. 364.
Anastasio F, Barbuto S, Scarnecchia E, Cosma P, Fugagnoli A, Rossi G. Medium-term impact of COVID-19 on pulmonary function, functional capacity and quality of life. Eur Respir J. 2021;58(3):2004015. doi: 10.1183/13993003.04015-2020
Huang Y, Tan C, Wu J, Chen M, Wang Z, Luo L, et al. Impact of coronavirus disease 2019 on pulmonary function in early convalescence phase. Respir Res. 2020;21(1):163. doi: 10.1186/s12931-020-01429-6
Gobbi M, Bezzoli E, Ismelli F, Trotti G, Cortellezzi S, Meneguzzo F, et al. Skeletal muscle mass, sarcopenia and rehabilitation outcomes in post-acute COVID-19 patients. J Clin Med. 2021;10(23):5623. doi: 10.3390/jcm10235623
Park CH, Yi Y, Do JG, Lee YT, Yoon KJ. Relationship between skeletal muscle mass and lung function in Korean adults without clinically apparent lung disease. Medicine (Baltimore). 2018;97(37):e12281. doi: 10.1097%2FMD.0000000000012281
Tieland M, Trouwborst I, Clark BC. Skeletal muscle performance and ageing. J Cachexia Sarcopenia Muscle. 2018;9(1):3-19. doi: 10.1002/jcsm.12238
Bone AE, Hepgul N, Kon S, Maddocks M. Sarcopenia and frailty in chronic respiratory disease. Chron Respir Dis. 2017;14(1):85-99. doi: 10.1177/1479972316679664
Alonso AC, Silva-Santos PR, Quintana MSL, Silva VC, Brech GC, Barbosa LG, et al. Physical and pulmonary capacities of individuals with severe coronavirus disease after hospital discharge: A preliminary cross-sectional study based on cluster analysis. Clinics. 2021;76:e3540. doi: 10.6061/clinics/2021/e3540
Moonen HPFX, Zanten FJLV, Driessen L, Smet V, Slingerland-Boot R, Mensink M, et al. Association of bioelectric impedance analysis body composition and disease severity in COVID-19 hospital ward and ICU patients: The BIAC-19 study. Clin Nutr. 2021;40(4):2328-36. doi: 10.1016%2Fj.clnu.2020.10.023
Kellnar A, Hoppe JM, Brunner S, Stremmel C. Hospitalization for COVID-19 is associated with significant changes in body composition. Clin Nutr. ESPEN 2021;45:499-502. doi: 10.1016/j.clnesp.2021.07.033
Downloads
Publicado
Edição
Seção
Licença
Copyright (c) 2023 Juliano Giorgio Rosa Luccas, Larissa de Magalhães Doebeli Matias, Hiago Vinicius Costa Silva, Charlys Victor Sousa Aguiar, João Paulo Rodrigues Pacheco, Everton Teles Rodrigues, Juliana Ribeiro Fonseca Franco de Macedo, Adriana Claudia Lunardi, Elinaldo da Conceição dos Santos
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.
Autores que publicam nesta revista concordam com os seguintes termos:
Autores mantém os direitos autorais e concedem à revista o direito de primeira publicação, com o trabalho simultaneamente licenciado sob a Licença Creative Commons Attribution 4.0 que permite o compartilhamento do trabalho com reconhecimento da autoria e publicação inicial nesta revista.
Autores têm autorização para distribuição não-exclusiva da versão do trabalho publicada nesta revista (ex.: publicar em repositório institucional ou como capítulo de livro), com reconhecimento de autoria e publicação inicial nesta revista.