Influência da prática de exercício físico no pâncreas endócrino de ratas prenhes
DOI:
https://doi.org/10.33233/nb.v15i2.223Resumo
Objetivo: Agrupar os artigos que exploram os mecanismos pelos quais a prática do exercício físico atua sobre o pâncreas endócrino de ratas prenhes. Metodologia: Na base de dados do site National Center of Biotechnology Information (NCBI-Pubmed), foram utilizados 10 conjuntos de palavras-chave: 1) exercise, pregnancy, rat, pancreas; 2) training, pregnancy, rat, pancreas; 3) swimming, pregnancy, rat, pancreas; 4) exercise, pregnancy, rat, beta (β) cell; 5) training, pregnancy, rat, beta (β) cell; 6) swimming, pregnancy, rat, beta (β) cell; 7) exercise, pregnancy, rat, pancreatic islet; 8) training, pregnancy, rat, pancreatic islet; 9) training, pregnancy, rat, pancreatic islet; 10) swimming, pregnancy, rat, pancreatic islet. Discussão: A literatura mostra que a prática de exercício é capaz de alterar metabolica e morfologicamente o pâncreas de animais restritos não prenhes, além disso, observou-se que o exercício foi capaz de normalizar a secreção de insulina em ratas prenhes. Conclusão: Dependendo do tipo e intensidade com que é empregado, o exercício altera o pâncreas endócrino e é capaz de gerar uma reprogramação pancreática, porém, são necessários mais estudos para elucidar de forma mais precisa os mecanismos pelos quais o exercício realiza essas alterações.
Palavras-chave: exercício, prenhez, rato, pâncreas.Referências
Kordowich S, Mansouri A, Collombat P. Reprogramming into pancreatic endocrine cells based on developmental cues. Mol Cell Endocrinol 2009;315:11-8.
Meda P, Denef JF, Perrelet A, Orci L. Nonrandom distribution of gap junctions between pancreatic beta-cells. Am J Physiol 1980;238(3):C114-9.
Trimble ER, Halban PA, Wollheim CB, Renold AE. Functional differences between rat islets of ventral and dorsal pancreatic origin. J Clin Invest 1982;69(2):405-13.
Jorns A. Immunocytochemical and ultrastructural heterogeneities of normal and glibenclamide stimulated pancreatic beta cells in the rat. Virchows Archiv 1994;425(3):305-13.
Parsons JA, Brelje TC, Sorenson RL. Adaptation of islets of Langerhans to pregnancy: increased islet cell proliferation and insulin secretion correlates with the onset of placental lactogen secretion. Endocrinology 1992;130(3):1459-66.
Butler AE, Cao-Minh L, Galasso R, Rizza RA, Corradin A, Cobelli C, et al. Adaptive changes in pancreatic beta cell fractional area and beta cell turnover in human pregnancy. Diabetology. 2010;53:2167-76.
American Diabetes Association (ADA), 2015. http://care.diabetesjournals.org/content/33/Supplement_1/S3.full.pdf+html.
Davidson MB. Diabete mellitus diagnóstico e tratamento. 4a ed. Rio de Janeiro: Revinter; 2001.
Buchanan TA, Xiang AH. Gestational diabetes mellitus. J Clin Invest 2005;115(3):485-91.
Brankston GN, Mitchell BF, Ryan EA. Resistance exercise decreases the need for insulin in overweight women with gestational diabetes mellitus. Am J Obstet Gynecol 2004;190(1):188-93.
Weissgerber TL, Wolfe LA, Davies GA, Mottola MF. Exercise in the prevention and treatment of maternal-fetal disease: a review of the literature. Appl Physiol Nutr Metab 2006;31(6):661-74.
Ceysens G, Rouiller D, Boulvain M. Exercise for diabetic pregnant women. Cochrane Database Syst Rev 2006 Jul 19;(3):CD004225.
Artal R, O'Toole M. Guidelines of the American College of Obstetricians and Gynecologists for exercise during pregnancy and the postpartum period. Br J Sports Med 2003;37(1):6-12.
Melzer K, Schutz Y, Boulvain M, Kayser B. Physical activity and pregnancy: cardiovascular adaptations, recommendations and pregnancy outcomes. Sports Med 2010;40(6):493-507.
Volpato GT, Damasceno DC, Campos KE, Rocha R, Rudge MVC, Calderon IMP. Avaliação do efeito do exercÃcio fÃsico no metabolismo de ratas diabéticas prenhes. Rev Bras Med Esporte 2006;12(5):229-33.
Volpato GT, Damasceno DC, Kempinas WG, Rudge MVC, Calderon IMP. Effect of exercise on the reproductive outcome and fetal development of diabetic rats. Reprod Biomed Online 2009;19(6):852-8.
Damasceno DC, Silva HP, Vaz GF, Vasques-Silva FA, Calderon IMP, Rudge MVC, et al. Diabetics rats exercised prior to and during pregnancy: maternal reproductive outcome, biochemical profile and frequency of fetal anomalies. Reprod Sci 2013;20(7):730-8.
Corvino SB, Volpato GT, Rudge MV, Damasceno DC. Intrauterine growth restricted rats exercised before and during pregnancy: maternal and perinatal repercussions. Evid Based Complement Alternat Med 2015;2015:1-10.
Corvino SB, Netto AO, Sinzato YK, Campos KE, Calderon IM, Rudge MV, Volpato GT, Zambrano E, Damasceno DC. Intrauterine growth restricted rats exercised at pregnancy: maternal-fetal repercussions. Reprod Sci 2015;22(8):991-9.
Farrell PA, Caston AL, Rodd D. Changes in insulin response to glucose after exercise training in partially pancreatectomized rats. J Appl Physiol 1991;70:1563-8.
Dela F, von Linstow ME, Mikines KJ, Galbo H. Physical training may enhance beta-cell function in type 2 diabetes. Am J Physiol Endocrinol Metab. 2004;287:E1024-31.
Park S, Hong SM, Lee JE, Sung SR. Exercise improves glucose homeostasis that has been impaired by a high-fat diet by potentiating pancreatic b-cell function and mass through IRS2 in diabetic rats. J Appl Physiol. 2007;103:1764-71.
Park S, Hong SM, Sung SR. Exendin-4 and exercise promotes b-cell function and mass through IRS2 induction in islets of diabetic rats. Life Sci 2008;82:503-11.
Calegari VC, Abrantes JL, Silveira LR, Paula FM, Costa Junior JM, Rafacho A et al. Endurance training stimulates growth and survival pathways and the redox balance in rat pancreatic islets. J App Physiol 2011;112:711-8.
Gatford KL, Kaur G, Falcão-Tebas F, Wadley GD, Wlodek ME, Laker RC et al. Exercise as an intervention to improve metabolic outcomes after intrauterine growth restriction. Am J Physiol Endocrinol Metab 2013;306:999-1012.
Laker RC, Gallo LA, Wlodek ME, Siebel AL, Wadley GD, McConell GK. Short-term exercise training early in life restores déficits in pancreatic ï¢-cell mass associated with growth restriction in adult male rats. Am J Physiol Endocrinol Metab 2011;301:931-40.
Wadley GD, Siebel AL, Cooney GJ, McConell GK, Wlodek ME, Owens JA. Uteroplacental insufficiency and reducing litter size alters skeletal muscle mitochondrial biogenesis in a sex specific manner in the adult rat. Am J Physiol Endocrinol Metab 2008;294:E861-9.
Mootha VK, Hosker JP, Eriksson KF, Subramanian A, Sihag S, Lehar J, Puigserver P, Carlsson E, Ridderstrale M, Laurila E, Houstis N, Daly MJ, Patterson N, Mesirov JP, Golub TR, Tamayo P, Spiegelman B, Lander ES, Hirschhorn JN, Altshuler D, Groop LC. PGC- 1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat Genet. 200;334:267-73.
Patti ME. Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: potential role of PGC1 and NRF1. Proc Natl Acad Sci USA 2003;100:8466-71.
Laker RC, Wlodek ME, Wadley GD, Gallo LA, Meukle PJ, McConell GK. Exercise early in life in rats born small does not normalize reductions in skeletal muscle PGC-1ï¡ in adultohood. Am J Physiol Endocrinol Metab 2012;301:1221-30.
Leandro CG, Fidalgo M, Bento-Santos A, Falcão-Tebas F, Vasconcelos D, de Castro RM et al. Maternal moderate physical training during pregnancy attenunates the effects of a low-protein diet on the impaired secretion of insulin in rats: potential role for compensation of insulin resistance and preventing gestational Diabetes mellitus. J Biomed Biotechnol 2012(2012):1-7.
Lowry OH, Passonneau JV. A flexible system of enzymatic analysis. New York, NY: Academic; 1972.
Barker DJ, Hales CN, Fall CH, Osmond C, Phipps K, Clark PM. Type 2 (non-insulin-dependent) Diabetes mellitus, hypertension and hyperlipidaemia (syndrome X): relation to reduced fetal growth. Diabetologia 1993;36:62-7.
Meikle PJ, Duplock S, Blacklock D, Whitfield PD, MacIntoch G, Hopwood JJ, Fuller M. Effect of lysosomal storage on bis(monoacylglycero) phosphate. Biochem J 2008;411:71-8.
Amati F, Dubé JJ, Alvarez-Carnero E, Edreira MM, Chomczynski P, Coen PM, Switzer GE, Bickel PE, Stefanovic-Racic M, Toledo FG, Goodpaster BH. Skeletal muscle triglycerides, diacylglycerols, and ceramides in insulin resistance: another paradox in endurance-trained athletes? Diabetes 2011;60: 2588-597.
O’Dowd R, Kent JC, Moseley JM, Wlodek ME. Effects of uteroplacental insufficiency and reducing litter size on maternal mammary function and postnatal offspring growth. Am J Physiol Regul Integr Comp Physiol 2008;294:R539-48.
Huber K, Miles JL, Norman AM, Thompson NM, Davison M, Breier BH. Prenatally induced changes in muscle structure and metabolic function facilitate exercise-induced obesity prevention. Endocrinology 2009;150:4135-44.
