O efeito de suplementação de simbióticos e exercícios aeróbios sobre a inflamação sistêmica em indivíduos idosos obesos
DOI:
https://doi.org/10.33233/rbfe.v16i4.1343Abstract
O processo de envelhecimento traz consigo alterações fisiológicas associadas ao avanço da idade que singulariza um aumento na produção de citocinas pró-inflamatórias, caracterizando uma condição de inflamação crônica de baixo grau. O objetivo deste estudo é verificar os benefícios da suplementação de substância simbiótica junto com exercícios aeróbios, diminuindo a inflamação sistêmica de idosos obesos. Indicando a hipótese de que esta inflamação de baixo nível está associada a um desequilíbrio na microbiota, a alterações na permeabilidade intestinal e a diminuição com exercícios aeróbicos, que estimulam, através da contração muscular, a produção de interleucina-6 (IL-6) que promove um ambiente anti-inflamatório. A estratégia de busca desenvolvida foi encontrar artigos controlados que avaliaram os parâmetros inflamatórios em indivíduos idosos obesos tendo um resultado significativo. Portanto, o uso de substâncias simbióticas e o exercício físico são capazes de reduzir a produção e a ação de marcadores inflamatórios, podendo prevenir doenças crônicas de baixo grau.
Palavras-chave: exercício físico, microbiota, inflamação, sistema imunológico, interleucinas.Â
References
Jeckel-Neto EA, Cunha GL. Teorias biológicas do envelhecimento. In: Freitas ET & Neri AL, eds. Tratado de Geriatria e Gerontologia. Rio de Janeiro: Guanabara Koogan; 2006. p.14-34
Yudkin JS, Stehouwer CD, Emeis JJ, Coppack SW. C-reactive protein in healthy subjects: associations with obesity, insulin resistance, and endothelial dysfunction: a potential role for cytokines originating from adipose tissue? Arterioscler Thromb Vasc Biol 1999;19:972-8.
Engström G, Hedblad B, Stavenow L, Lind P, Janzon L, Lindgärde F. Inflammation-sensitive plasma proteins are associated with future weight gain. Diabetes 2003;52:2097-101.
Zamboni M, Mazzali G. Obesity in the elderly: an emerging health issue. Int J Obesity 2012;36(9):1151-2.
Cani PD, Delzene NM. The role of the gut microbiota in energy metabolism and metabolic disease. Curr Pharm Design 2009;15(13):1546-58.
Manco M, Putignani L, Bottazzo GF. Gut microbiota, lipopolysaccharides, and innate immunity in the pathogenesis of obesity and cardiovascular risk. End Rev 2010;31(6):817-44.
Pendyala S, Walker JM. Holt, P.R. A high-fat diet is associated with endotoxemia that originates from the gut. Gastroenteroloy 2012;142:1100-1.
Simpson RJ, Lowder TW, Spielmann G, Bigley AB, La Voy EC, Kunz H. Exercise and the aging immune system. Ageing RR 2012;11(3):404-20.
Schwarz NA, Rigby BR, Bounty P, Shelmadine B. A review of weight control strategies and their effects on the regulation of hormonal balance. J Nutr Metab 2011;15.
Thomas GA, Kraemer WJ, Comstock BA, Dunn-Lewis C, Volek JS, Denegar CR, Maresh CM. Effects of resistance exercise and obesity level on ghrelin and cortisol in men. Metabolism 2012; 61(6)860-8.
Gleeson M, Bishop NC, Stensel DJ, Lindley MR, Mastana SS, Nimmo MA. The anti-inflammatory effects of exercise: mechanisms and implications for the prevention and treatment of disease. Nat Rev Immunol 2011;11:607-15.
Singh T, Newman AB. Inflammatory markers in population studies of aging. Ageing Res Rev 2011;10319-29.
Lara J, Cooper R, Nissan J, Ginty AT, Khaw KT, Deary IJ et al. A proposed panel of biomarkers of healthy ageing. Biomed Central 2015;13:222.
Ashley NT, Weil ZM, Nelson RJ. Inflammation: Mechanisms, Costs, and Natural Variation. Annu Rev Ecol Evol Syst 2012;43:385-406.
Cildir G, Akincilar SC, Tergaonkar V. Chronic adipose tissue inflammation: all immune cells on the stage. Trends Mol Med 2013;19(8):487-500.
Ferrerira FC, Ferreira FC, de Medeiros AI, Nicioli C, Nunes JE, Shiguemoto GE, Prestes J et al. Circuit resist training in sedent women: body composition and serum cytokine levels. Appl Physiol Nutr Metab 2009;35(2):23-9.
Belotto MF. Efeito do exercÃcio fÃsico sobre o estado inflamatório de diabéticos. [citado 2016 Dez 2]. DisponÃvel em UR: http://www.efdeportes.com/efd159/efeito-do-exercicio-fisico-sobre-diabeticos.htm.
Ouchi N, Parker JL, Lugus JJ, Walsh K. Adipokines in inflammation and metabolic disease. Nat Rev Immunol 2011;11(2):85-97.
Petersen AMW, Perdersen BK. The role of IL-6 in mediating the anti-inflammatory effects of exercise. J Physiol Pharmacol 2006;10:43-51.
Kennedy RL, Chokkalingham K, Srinivasan R. Obesity in the elderly: who should we be treating, and why, and how? Clinical Nutrition and Metabolic Care 2004;7:3-9.
Junqueira LC, Carneiro J. Biologia Celular e Molecular. 9 ed. Rio de Janeiro: Guanabara Koogan; 2013.
Gano LB, Donato AJ, Pierce GL, Pasha HM, Magerko KA, Roeca C. Increased proinflammatory and oxidant gene expression in circulating mononuclear cells in older adults: amelioration by habitual exercise. Physiol Genomics 2011;43(14):895-902.
Mendham AE, Duffield R, Marino F, Coutts AJ. Small-sided games training reduces CRP, IL-6 and leptin in sedentary, middle-aged men. Eur J Appl Physiol 2014;114(11):2289-97.
Tartibian B, FitzGerald LZ, Azadpour N, Maleki BH. A randomized controlled study examining the effect of exercise on inflammatory cytokine levels in post-menopausal women. Post Reprod Health 2015;21(1):9-15.
Thompson D, Markovitch D, Betts JA, Mazzatti D, Turner J, Tyrrell RM (1985). Time course of changes in inflammatory markers during a 6-mo exercise intervention in sedentary middle-aged men: a randomized-controlled tri. J Appl Physiol 2010;108(4):769-79.
Inglis JE, Ilich JZ. The microbiome and osteosarcopenic obesity in older individuals in long-term care facilities. Curr Ost Rep 2015;13(5):358-62.
Remely M, Hippe B, Geretschlaeger I, Stegmayer S, Hoefinger I, Haslberger A. Increased gut microbiota diversity and abundance of Faecalibacterium prausnitzii and Akkermansia after fasting: a pilot study. Wien Klin Wochenschr 2015;127(9-10:394-8.
Sato J, Kanazawa A, Ikeda F, Yoshihara T, Goto H, Abe H, et al. Research in National Center for Biotechnology Information. Diabetes Care 2014;37(8):2343-50.
Lee J, Bose S, Seo JG, Chung WS, Lim CY, Kim H. The effects of co-administration of probiotics with herbal medicine on obesity, metabolic endotoxemia and dysbiosis: a randomized double-blind controlled clinical trial. Clin Nutr 2014;33(6):973-81.
Leber B, Tripolt NJ, Blattl D, Eder M, Wascher TC, Pieber TR, et al. The influence of probiotic supplementation on gut permeability in patients with metabolic syndrome: an open label, randomized pilot study. Eur J Clin Nutr 2012;66:1110-15.
Qun Yan, Xu Li, Bo Feng. The efficacy and safety of probiotics intervention in preventing conversion of impaired glucose tolerance to diabetes: study protocol for a randomized, double-blinded, placebo controlled trial of the Probiotics Prevention Diabetes Programme (PPDP). BMC Endocrine Disorders 2015. [citado 2016 dez 5]. DisponÃvel em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666047
Woodard GA, Encarnacion B, Downey JR, Peraza J, Chong K, Hernandez-Boussard T et al. Probiotics improve outcomes after Roux-en-Y gastric bypass surgery: a prospective randomized trial. J Gastrointest Surg 2009;13:1198-204.
Marques, Mota J, Viana JL, Tuna D, Figueiredo P, Guimarães JT, Carvalho J et al. Response of bone mineral density, inflammatory cytokines, and biochemical bone markers to a 32-week combined loading exercise program in older men and women, Arch Gerontol Geriatr 2013;57(2):226-33.
So WY, Song M, Park YH, Cho BL, Lim JY, Kim SH, Song W. Body composition, fitness level, anabolic hormones, and inflammatory cytokines in the elderly: a randomized controlled trial. Aging Clin Exp Res 2013;25(2):167-74.
Pedersen BK. IL-6 signalling in exercise and disease. Biochem Soc Trans 2007;35:1295-7.
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