Effect of α-lipoic acid supplementation on oxidative stress of heart and liver tissues of endurance-trained mice submitted to an exhaustive exercise
DOI:
https://doi.org/10.33233/rbfex.v20i3.4205Keywords:
physical exercise; oxidative stress, lipoic acidAbstract
Introduction: High intensity exercise causes an increase in reactive oxygen species production, which can be harmful to the health and function of several organ tissues. Objective: To analyze the effect of supplementation with α-lipoic acid against the oxidative stress in the heart and liver of endurance-trained mice submitted to the exhaustive endurance exercise bout. Methods: Thirty-two male mice were submitted to 6-week endurance swimming training, and divided in two groups according to supplementation protocol, α-lipoic acid or vehicle, during the last two weeks. The last training session was destined to the exhaustive exercise bout. It was analyzed the lipid peroxidation, oxidative damage to proteins and antioxidant marker in liver and heart immediately (0h) and four-hours (4h) after the exhaustive exercise in both groups. Results: The heart of supplemented animals showed a lower protein damage and higher levels of antioxidant in 0h and 4h. In the liver, lipid peroxidation was higher in supplemented animals in 0h but did not differ 4h after the exhaustion. The liver of supplemented animals showed higher levels of carbonylated protein in both 0h and 4h. Conclusion: The α-lipoic acid supplementation is an efficient antioxidant to the heart of trained mice submitted to exhaustive exercise but is unnecessary to avoid exhaustion-induced oxidative stress in the liver.
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Copyright (c) 2021 Letícia Santana Wolf, Alisson de Carvalho Goncalves, Ruan Carlos Macedo de Moraes, Ana Carolina Nunes Rodrigues, Susana Merino, Guilherme Vannucchi Portari
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