Inflammatory profile and tissue injury in runners (5, 10, 15 km) and ultramarathon: IL-6, myoglobin
Original article - e255653 - Published 2026,Abr 2
DOI:
https://doi.org/10.33233/rbfex.v25i1.5653Keywords:
interleukin-6, myoglobin, running, inflammation, biomarkers, muscle fatigueAbstract
Introduction: Understanding the inflammatory responses and changes in muscle damage biomarkers induced by endurance exercise is crucial for optimizing training and recovery protocols. Method: This study analyzed interleukin-6 (IL-6) and myoglobin (MYO) levels in 75 recreational runners in Vitória-ES, across distances of 5, 10, 15 km, and a 12-hour ultramarathon (79.93 ± 28.65 km). The runners had average paces of 5.19 ± 1.22 min/km (5 km), 5.16 ± 0.57 min/km (10 km), 4.36 ± 0.12 min/km (15 km), and 10.91 ± 5.83 min/km (ultramarathon). Capillary blood samples were collected using micro EDTA tubes, with digital puncture and automatic lancets, and analyzed by point of care testing (POCT) technology. Results: 5 km, IL-6 decreased by 27.30% and MYO increased by 240.41%. 10 km, IL-6 decreased by 13.99% and MYO increased by 343.31%. 15 km, IL-6 decreased by 3.10% and MYO increased by 1062.61%. Ultramarathon IL-6: Pre: 7.66 ± 3.77 pg/ml, Mid-race: 48.55 ± 81.57 pg/ml (+ 533.68%), Post-race: 26.54 ± 20.82 pg/ml (-91.84% relative to pre-exercise). Eight days later: 4.07 ± 1.47 pg/ml (-46.86% relative to pre-exercise). Myoglobin: Pre: 22.42 ± 19.73 ng/ml, Mid-race: 314.19 ± 160.76 ng/ml (+ 1300.85%), Post-race: 423.07 ± 149.65 ng/ml (+1787.20% relative to pre-exercise). Eight days later: 40.50 ± 18.81 ng/ml (+ 80.70% relative to pre-exercise). Conclusion: The variability in responses reinforces the need for monitoring and individualized approaches, considering biopositive and bionegative adaptations resulting from biological individuality and physiological capacity.
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