Neuromuscular electrostimulation in patients with heart failure: A systematic review with meta-analysis

Review - e255658 - Published 2026, Jun 3 16

Authors

DOI:

https://doi.org/10.33233/rbfex.v25i1.5658

Keywords:

heart failure, transcutaneous electrical nerve stimulation, quality of life, muscle strength, functional status

Abstract

 

Introduction: Chronic Heart Failure (CHF) occurs when the heart is unable to meet the body's demands adequately, resulting in reduced blood flow. The patient experiences dyspnea, fatigue, and an inability to perform exercises that require greater effort. Neuromuscular electrostimulation (NMES) has been used as a treatment to increase muscle strength, functional capacity, and quality of life. Objective: To review the effectiveness of NMES on muscle strength, quality of life, and functional capacity in patients with heart failure. Methods: This is a systematic review using the PICO strategy, with searches conducted in the PUBMED, SciELO, and LILACS databases using the descriptors: heart failure, transcutaneous electrical nerve stimulation, quality of life, muscle strength, and functional status, combined with the boolean operators 'AND' and 'OR'. Results: Eighteen studies were included after selection. NMES showed no statistically significant difference on the functional capacity outcome (difference between means 12.06 meters; 95% CI, -2.55 to +26.66), but there was a statistically significant difference in quality of life (difference between means 4.20 points; 95% CI, 2.79 to 5.62). The studies showed superiority in muscle strength for patients with CHF who were exposed to NMES. Conclusion: Neuromuscular electrostimulation can safely be implemented in patients with heart failure, positively impacting quality of life and muscle strength, but without affecting functional capacity.

Author Biographies

Aline de Sousa Nassif, UNIFAN

Centro Universitário Nobre, Feira de Santana, BA, Brasil

Fernanda Lobo de Jesus Brito, UNIFAN

Centro Universitário Nobre, Feira de Santana, BA, Brasil

Gilmara Santa Rosa Santos, UNIFAN

Centro Universitário Nobre, Feira de Santana, BA, Brasil

André Luiz Cordeiro, UNIFAN

Centro Universitário Nobre, Feira de Santana, BA, Brasil

References

1. Murphy SP, Ibrahim NE, Januzzi JL Jr. Heart failure with reduced ejection fraction: a review. JAMA. 2020;324(5):488-504. doi: 10.1001/jama.2020.10262. Erratum in: JAMA. 2020;324(20):2107. doi: 10.1001/jama.2020.21736

2. Dawson A, Bonner C, Donald M, et al. The role of physical activity in heart failure rehabilitation: an update. Eur J Prev Cardiol. 2020;27(2):123-33. doi: 10.1016/j.jacc.2011.04.020

3. Mounsey LA, Guo M, Lau ES, Ho JE. Exercise training in heart failure: clinical benefits and mechanisms. Circ Res. 2025 Jul 7;137(2):273-89. doi: 10.1161/CIRCRESAHA.124.325533

4. Coletti RH. The ischemic model of chronic muscle spasm and pain. Eur J Transl Myol. 2022;32(1):10323. doi: 10.4081/ejtm.2022.10323

5. Ploesteanu RL, Nechita AC, Turcu D, Manolescu BN, Stamate SC, Berteanu M. Effects of neuromuscular electrical stimulation in patients with heart failure - review. J Med Life. 2018;11(2):107-18

6. Carraro U, Rigatelli G, Rossini K, Barbiero M, Rigatelli G. Demand dynamic bio-girdling in heart failure: improved efficacy of dynamic cardiomyoplasty by LD contraction during aortic out-flow. Int J Artif Organs. 2003;26(3):217-24. doi: 10.1177/039139880302600307

7. Jones S, Man WD, Gao W, Higginson IJ, Wilcock A, Maddocks M. Neuromuscular electrical stimulation for muscle weakness in adults with advanced disease. Cochrane Database Syst Rev. 2016;10(10):CD009419. doi: 10.1002/14651858.CD009419.pub3

8. Guilherme D, Ferreira M, Oliveira E. Tailoring neuromuscular electrical stimulation protocols in heart failure patients: A review. J Cardiopulm Rehabil Prev. 2022;42(3):159-67. doi: 10.18103/mra.v10i12.3369

9. Gomes Neto M, Oliveira FA, Reis HF, de Sousa Rodrigues- E Jr, Bittencourt HS, Oliveira Carvalho V. Effects of neuromuscular electrical stimulation on physiologic and functional measurements in patients with heart failure: A systematic review with meta-analysis. J Cardiopulm Rehabil Prev. 2016;36(3):157-66. doi: 10.1097/HCR.0000000000000151

10. Maddocks M, Gao W, Higginson IJ, Wilcock A. Neuromuscular electrical stimulation for muscle weakness in adults with advanced disease. Cochrane Database Syst Rev. 2013;(1):CD009419. doi: 10.1002/14651858.CD009419.pub2. Update in: Cochrane Database Syst Rev. 2016;10:CD009419. doi: 10.1002/14651858.CD009419.pub3

11. Maher D, Liberati A, Tetzlaff J, Altman DG, The PRISMA Group. Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement. PLoS Med.2009;6(7):e1000097.

12. Santos CMC, Pimenta CAM, Nobre MR. The PICO strategy for the research question construction and evidence search. Rev Lat Am Enfermagem. 2007;15(3):508-11. doi: 10.1590/s0104-11692007000300023

13. Maher CG, Sherrington C, Herbert RD, Moseley AM, Elkins M. Reliability of the PEDro scale for rating quality of randomized controlled trials. Phys Ther. 2003;83(8):713-21. PMID: 12882612

14. Dobsák P, Nováková M, Fiser B, Siegelová J, Balcárková P, Spinarová L, et al. Electrical stimulation of skeletal muscles. An alternative to aerobic exercise training in patients with chronic heart failure? Int Heart J. 2006;47(3):441-53. doi: 10.1536/ihj.47.441

15. Deley G, Kervio G, Verges B, Hannequin A, Petitdant MF, Salmi-Belmihoub S, et al. Comparison of low-frequency electrical myostimulation and conventional aerobic exercise training in patients with chronic heart failure. Eur J Cardiovasc Prev Rehabil. 2005;12(3):226-33. doi: 10.1097/01.hjr.0000166455.23346.a5

16. Deley G, Eicher JC, Verges B, Wolf JE, Casillas JM. Do low-frequency electrical myostimulation and aerobic training similarly improve performance in chronic heart failure patients with different exercise capacities? J Rehabil Med. 2008;40(3):219-24. doi: 10.2340/16501977-0153

17. Eicher JC, Dobsak P, Berteau O, Walker P, Verges B, Maillefert JF, et al. Rehabilitation in chronic congestive heart failure: comparison of bicycle training and muscle electrical stimulation. Scr Med (Brno) 2004;77(5–6): 261–70.

18. Harris S, LeMaitre JP, Mackenzie G, Fox KA, Denvir MA. A randomised study of home-based electrical stimulation of the legs and conventional bicycle exercise training for patients with chronic heart failure. Eur Heart J. 2003;24(9):871-8. doi: 10.1016/s0195-668x(02)00822-9

19. Karavidas AI, Raisakis KG, Parissis JT, Tsekoura DK, Adamopoulos S, Korres DA, et al. Functional electrical stimulation improves endothelial function and reduces peripheral immune responses in patients with chronic heart failure. Eur J Cardiovasc Prev Rehabil. 2006;13(4):592-7. doi: 10.1097/01.hjr.0000219111.02544.ff

20. Araújo CJ, Gonçalves FS, Bittencourt HS, dos Santos NG, Mecca Junior SV, Neves JL, et al. Effects of neuromuscular electrostimulation in patients with heart failure admitted to ward. J Cardiothorac Surg. 2012;7:124. doi: 10.1186/1749-8090-7-124

21. Banerjee P, Caulfield B, Crowe L, Clark AL. Prolonged electrical muscle stimulation exercise improves strength, peak VO2, and exercise capacity in patients with stable chronic heart failure. J Card Fail. 2009;15(4):319-26. doi: 10.1016/j.cardfail.2008.11.005

22. Karavidas A, Parissis J, Arapi S, Farmakis D, Korres D, Nikolaou M, et al. Effects of functional electrical stimulation on quality of life and emotional stress in patients with chronic heart failure secondary to ischaemic or idiopathic dilated cardiomyopathy: a randomised, placebo-controlled trial. Eur J Heart Fail. 2008;10(7):709-13. doi: 10.1016/j.ejheart.2008.05.014

23. Karavidas A, Driva M, Parissis JT, Farmakis D, Mantzaraki V, Varounis C, et al. Functional electrical stimulation of peripheral muscles improves endothelial function and clinical and emotional status in heart failure patients with preserved left ventricular ejection fraction. Am Heart J. 2013;166(4):760-7. doi: 10.1016/j.ahj.2013.06.021

24. Nuhr MJ, Pette D, Berger R, Quittan M, Crevenna R, Huelsman M, et al. Beneficial effects of chronic low-frequency stimulation of thigh muscles in patients with advanced chronic heart failure. Eur Heart J. 2004;25(2):136-43. doi: 10.1016/j.ehj.2003.09.027

25. Quittan M, Wiesinger GF, Sturm B, Puig S, Mayr W, Sochor A, et al. Improvement of thigh muscles by neuromuscular electrical stimulation in patients with refractory heart failure: a single-blind, randomized, controlled trial. Am J Phys Med Rehabil. 2001;80(3):206-14. doi: 10.1097/00002060-200103000-00011

26. Groehs RV, Antunes-Correa LM, Nobre TS, Alves MJ, Rondon MU, Barreto AC, et al. Muscle electrical stimulation improves neurovascular control and exercise tolerance in hospitalised advanced heart failure patients. Eur J Prev Cardiol. 2016 Oct;23(15):1599-608. doi: 10.1177/2047487316654025

27. Sacilotto MCB, Lavagnoli CFR, Silveira-Filho LM, Vilarinho KAS, Oliveira ESB, Carvalho DD, et al. A simpler and shorter neuromuscular electrical stimulation protocol improves functional status and modulates inflammatory profile in patients with end-stage congestive heart failure. Int. J. Cardiovasc. Sci. 2017;30(6):484-95. doi: 10.5935/2359-4802.20170064.

28. Kucio C, Stastny P, Leszczyńska-Bolewska B, Engelmann M, Kucio E, Uhlir P, et al. Exercise-based cardiac rehabilitation with and without neuromuscular electrical stimulation and its effect on exercise tolerance and life quality of persons with chronic heart failure. J Hum Kinet. 2018;65:151-64. doi: 10.2478/hukin-2018-0045

29. Forestieri P, Bolzan DW, Santos VB, Moreira RSL, de Almeida DR, Trimer R, et al. Neuromuscular electrical stimulation improves exercise tolerance in patients with advanced heart failure on continuous intravenous inotropic support use-randomized controlled trial. Clin Rehabil. 2018;32(1):66-74. doi: 10.1177/0269215517715762

30. Ennis S, McGregor G, Hamborg T, Jones H, Shave R, Singh SJ, et al. Randomised feasibility trial into the effects of low-frequency electrical muscle stimulation in advanced heart failure patients. BMJ Open. 2017;7(8):e016148. doi: 10.1136/bmjopen-2017-016148

31. Kadoglou NP, Mandila C, Karavidas A, Farmakis D, Matzaraki V, Varounis C, et al. Effect of functional electrical stimulation on cardiovascular outcomes in patients with chronic heart failure. Eur J Prev Cardiol. 2017;24(8):833-39. doi: 10.1177/2047487316687428

Published

2026-05-31