Obesity and exercise immunology: implication in times of COVID-19 pandemic

Autores/as

  • Guilherme Gomes Azizi UFRJ
  • Marco Orsini UNIG
  • Sérgio Duarte Dortas Júnior UFRJ
  • Sandro de Albuquerque Cerbino Santa Casa de Misericórdia do Rio de Janeiro

DOI:

https://doi.org/10.33233/rbfe.v19i2.4117

Resumen

Obesity is a major worldwide epidemic, which places a burden on society and the public health system, affecting people of all ages and all social groups in developed and developing countries, reaching 650 million worldwide [1]. Thereby, we discuss the association between obesity inflammatory state and SARS-COV-2 infection, and the role of exercise immunology as a weapon and fundamental character to the health for million people in this pandemic time....

Biografía del autor/a

Guilherme Gomes Azizi, UFRJ

Serviço de Imunologia, Hospital Universitário Clementino Fraga Filho (HUCFF-UFRJ),  Fluminense Football Club

 

Marco Orsini, UNIG

Universidade Iguaçu – UNIG, Serviço de Neurologia/Neurocirurgia Universidade Federal Fluminense– UFF, Universidade de Vassouras - USS

Sérgio Duarte Dortas Júnior, UFRJ

Serviço de Imunologia, Hospital Universitário Clementino Fraga Filho (HUCFF-UFRJ),  Departamento de Clí­nica Médica- Universidade Federal do Rio de Janeiro- UFRJ

 

Sandro de Albuquerque Cerbino, Santa Casa de Misericórdia do Rio de Janeiro

Serviço de Endocrinologia do Hospital Geral da Santa Casa de Misericórdia do Rio de Janeiro

Citas

Mancini MC et al. Tratado de obesidade 2 ed. Rio de Janeiro: Guanabara Koogan; 2015.

Li Q, Guan X, Wu P, Wang X, Zhou L, Tong Y, Ren R, Leung KSM, Lau EHY, Wong JY et al. Early transmission dynamics in Wuhan, China, of novel coronavirus–infected pneumonia. N Engl J Med 2020;382(13):1199-207. https://doi.org/10.1056/nejmoa2001316

World Health Organization Press Conference. The World Health Organization (WHO) has officially named the disease caused by the novel coronavirus as COVID-19. https://www.who.int/emergencies/diseases/novel-coronavirus-2019/events-as-they-happen

Gorbalenya AE, Baker SC, Baric RS, de Groot RJ, Drosten C, Gulyaeva AA, Haagmans BL, Lauber C, Leontovich AM, Neuman BW et al. Severe acute respiratory syndrome-related coronavirus: The species and its viruses—A statement of the Coronavirus Study Group. Nature Microbiology https://doi.org/10.1038/s41564-020-0695-z

Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, Zhao X, Huang B, Shi W, Lu R et al. A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med 2020;382(8):727-33. https://doi.org/10.1056/nejmoa2001017

Zhou P, Yang XL, Wang XG, Hu B, Zhang L, Zhang W, Si HR, Zhu Y, Li B, Huang CL et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature 2020;579(7798):270-3. https://doi.org/10.1038/s41586-020-2012-7

Weiss SR, Leibowitz JL. Coronavirus pathogenesis. Advance in virus research; 2011. p.85-164. https://doi.org/10.1016/b978-0-12-385885-6.00009-2

Zhang JJ, Dong X, Cao YY, Yuan YD, Yang YB, Yan YQ, Akdis CA, D. Clinical characteristics of 140 patients infected with SARS-CoV-2 in Wuhan, China. Allergy 27/02/2020. https://doi.org/10.1111/all.14238

Arentz M, Yim E, Klaff L, Lokhandwala S, Riedo FX, Chong M, Lee M. Characteristics and outcomes of 21 critically Ill patients with COVID-19 in Washington State. JAMA 2020;323(16):1612. https://doi.org/10.1001/jama.2020.4326

Team TNCPERE. The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID-19) - China, 2020. China CDC Weekly 2020;2:113-22.

Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, Xiang J, Wang Y, Song B, Gu X, Guan L, Wei Y, Li H, Wu X, Xu J, Tu S, Zhang Y, Chen H, Cao B. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet 2020;395(10229):1054-62. https://doi.org/10.1016/S0140-6736(1020)30566-30563

Perlman S, Dandekar AA. Immunopathogenesis of coronavirus infections: implications for SARS. Nat Rev Immunol 2005;5(12):917-27. https://doi.org/10.1038/nri1732

Zumla A, Hui DS, Perlman S. Middle East respiratory syndrome. Lancet 2015;386(9997):995-1007. https://doi.org/10.1016/s0140-6736(15)60454-8

Pedersen SF, Ho YC. SARS-CoV-2: a storm is raging. J Clin Invest 2020;130(5):2202-5. https://doi.org/10.1172/jci137647

Mehta P, McAuley DF, Brown M, Sanchez E, Tattersall RS, Manson JJ et al. COVID-19: consider cytokine storm syndromes and immunosuppression. Lancet 2020;395(10229):1033-4. https://doi.org/10.1016/s0140-6736(20)30628-0

Herold TVJ, Arnreich C, Hellmuth JC, von Bergwelt-Baildon M, Klein M, Weinberger T. Level of IL-6 predicts respiratory failure in hospitalized symptomatic COVID-19 patients. medRxiv 2020. https://doi.org/10.1101/2020.04.01.20047381

Simonnet A, Chetboun M, Poissy J et al. High prevalence of obesity in severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) requiring invasive mechanical ventilation [published online ahead of print, 2020 Apr 9]. Obesity 2020. https://doi.org/10.1002/oby.22831

Festa A, D’Agostino R Jr, Williams K et al. (2001) The relation of body fat mass and distribution to markers of chronic inflammation. Int J Obes Relat Metab Disord 2001;25:1407-15. https://doi.org/10.1038/sj.ijo.0801792

Park HS, Park JY & Yu R. Relationship of obesity and viscera adiposity with serum concentrations of CRP, TNF-alpha and IL-6. Diabetes Res Clin Pract 2005;69:29-35. https://doi.org/10.1016/j.diabres.2004.11.007

Bulló M, García-Lorda P, Megias I et al. Systemic inflammation, adipose tissue tumor necrosis factor, and leptin expression. Obes Res 2003;11:525-31. https://doi.org/10.1038/oby.2003.74

Trayhurn P, Wood IS. Adipokines: inflammation and the pleiotropic role of white adipose tissue. Br J Nutr 2004;92:347-55. https://doi.org/10.1079/bjn20041213

Hotamisligil GS. Inflammation and metabolic disorders. Nature 2006;444:860-7. https://doi.org/10.1038/nature05485

Bastard JP, Maachi M, Lagathu C et al. Recent advances in the relationship between obesity, inflammation, and insulin resistance. Eur Cytokine Netw 2006;17:4-12.

Grenha AI et al. Obesidade e imunodepressão: Factos e números. Arq Med 2013;27(5):192-202.

Romeo J, Martínez-Gómez D, Díaz LE et al. Changes in cardiometabolic risk factors, appetite-controlling hormones and cytokines after a treatment programme in overweight adolescents: preliminary findings from the EVASYON study. Pediatric Diabetes 2011;12:372-80. https://doi.org/10.1111/j.1399-5448.2010.00753.x

Walsh NP, Gleeson M, Shephard RJ et al. Position statement. Part one: immune function and exercise. Exerc Immunol Rev 2011;17:6-63.

Campbell JP, Riddell NE, Burns VE et al. Acute exercise mobilises CD8+ T lymphocytes exhibiting an effector-memory phenotype. Brain Behav Immun 2009;23(6):767-75. https://doi.org/10.1016/j.bbi.2009.02.011

Simpson RJ, Florida-James GD, Whyte GP, Black JR, Ross JA, Guy K. Apoptosis does not contribute to the blood lymphocytopenia observed after intensive and downhill treadmill running in humans. Res Sports Med 2007;15(3):157-74. https://doi.org/10.1080/15438620701405339

Simpson RJ. The effects of exercise on blood leukocyte numbers. In: Gleeson M, Bishop NC, Walsh NP, eds. Exercise Immunology. Oxford, UK, New York, USA: Routledge; 2013. p.64-105. https://doi.org/10.4324/9780203126417

Nieman DC, Nehlsen-Cannarella SL, Fagoaga OR et al. Effects of mode and carbohydrate on the granulocyte and monocyte response to intensive, prolonged exercise. J Appl Physiol 1998;84(4):1252-9. https://doi.org/10.1152/jappl.1998.84.4.1252

Ortega E, Collazos ME, Maynar M, Barriga C, De la Fuente M. Stimulation of the phagocytic function of neutrophils in sedentary men after acute moderate exercise. Eur J Appl Physiol Occup Physiol 1993;66(1):60-4. https://doi.org/10.1007/bf00863401

Bishop NC, Gleeson M, Nicholas CW, Ali A. Influence of carbohydrate supplementation on plasma cytokine and neutrophil degranulation responses to high intensity intermittent exercise. Int J Sport Nutr Exerc Metab 2002;12(2):145-56. https://doi.org/10.1123/ijsnem.12.2.145

Pyne DB. Regulation of neutrophil function during exercise. Sports Med 1994;17(4):245-58. https://doi.org/10.2165/00007256-199417040-00005

Gleeson M, McDonald WA, Cripps AW, Pyne DB, Clancy RL, Fricker PA. The effect on immunity of long-term intensive training in elite swimmers. Clin Exp Immunol 1995;102:210-6. https://doi.org/10.1111/j.1365-2249.1995.tb06658.x

Lancaster GI, Halson SL, Khan Q, Drysdale P, Jeukendrup AE, Drayson MT, Gleeson M. Effect of acute exhaustive exercise and a 6-day period of intensified training on immune function in cyclists. J Physiol 2003;548P:O96. https://www.physoc.org/abstracts/effect-of-acute-exhaustive-exercise-and-a-6-day-period-of-intensified-training-on-immune-function-in-cyclists/

Lancaster GI, Halson SL, Khan Q, Drysdale P, Jeukendrup AE, Drayson MT, Gleeson M. The effects of acute exhaustive exercise and intensified training on type 1/type 2 T cell distribution and cytokine production. Exerc Immunol Rev 2004;10:91-106. https://www.ncbi.nlm.nih.gov/pubmed/15633589

Robson PJ, Blannin AK, Walsh NP, Bishop NC, Gleeson M. The effect of an acute period of intense interval training on human neutrophil function and plasma glutamine in endurance-trained male runners. J Physiol 1999;515:84-5.

Verde TJ, Thomas SG, Moore RW, Shek P, Shephard RJ. Immune responses and increased training of the elite athlete. J Appl Physiol 1992;73:1494-9. https://doi.org/10.1152/jappl.1992.73.4.1494

Yan H, Kuroiwa A, Tanaka H, Shindo M, Kiyonaga A, Nagayama A. Effect of moderate exercise on immune senescence in men. Eur J Appl Physiol 2001;86(2):105-11. https://doi.org/10.1007/s004210100521

Woods JA, Ceddia MA, Wolters BW, Evans JK, Lu Q, McAuley E. Effects of 6 months of moderate aerobic exercise training on immune function in the elderly. Mech Ageing Dev 1999;109(1):1-19. https://doi.org/10.1016/s0047-6374(99)00014-7

Simpson RJ, Lowder TW, Spielmann G, Bigley AB, Lavoy EC, Kunz H. Exercise and the aging immune system. Ageing Res Rev 2012;11:404-20. https://doi.org/10.1016/j.arr.2012.03.003

ElKassar N, Gress RE. An overview of IL-7 biology and its use in immunotherapy. J Immunotoxicol 2010;7(1):1-7. https://doi.org/10.3109/15476910903453296

Dvorak J, Junge A, Derman W, Schwellnus M. Injuries and illnesses of football players during the 2010 FIFA World Cup. Br J Sports Med 2011;45(8):626-30. https://doi.org/10.1136/bjsm.2010.079905

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Publicado

2020-05-10

Número

Vol. 19 Núm. 2 (2020): Suplemento COVID-19

Sección

Opinion

Licencia

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