Exercício físico como terapia adjuvante para o câncer de mama: uma revisão sobre as evidências atuais e perspectivas do exercício em oncologia

Autores/as

DOI:

https://doi.org/10.33233/rbfex.v20i4.4789

Palabras clave:

neoplasias da mama; exercício físico; fadiga; aptidão cardiorrespiratória

Resumen

Objetivo: Descrever os efeitos e os moderadores do exercício físico na fadiga e capacidade cardiorrespiratória de pacientes com câncer de mama em tratamento primário, bem como a relação entre o exercício físico e sobrevida nessa população. Métodos: Foi realizada uma revisão narrativa de estudos que examinaram os efeitos do exercício na fadiga e capacidade cardiorrespiratória em mulheres com câncer de mama. Além disso, examinamos informações relevantes sobre a relação entre exercício e sobrevivência em pacientes com câncer. Resultados: O exercício reduziu significativamente a fadiga relacionada ao câncer com maiores reduções observadas em pacientes que realizaram exercício de forma supervisionada ou apresentaram maiores queixas de fadiga. Na capacidade cardiorrespiratória, aumentos significativos foram observados após a realização de programas baseados em treinamento aeróbio. Pacientes mais jovens, que realizaram programas supervisionados, ou que participaram de prescrição não-lineares de treinamento aeróbio apresentaram maiores efeitos. Apesar de estudos epidemiológicos indicarem associações entre maiores níveis de atividade física e sobrevivência, ensaios clínicos randomizados são necessários para confirmar tal relação em pacientes com câncer. Conclusão: Sugerimos a promoção do exercício na redução da fadiga e aumento da capacidade cardiorrespiratória em mulheres com câncer de mama. Além disso, grupos específicos de pacientes baseados na idade e níveis iniciais parecem responder melhor ao exercício que outros.

 

Biografía del autor/a

Pedro Lopez, Edith Cowan University

Doutorando na Edith Cowan University (ECU/ Australia), e vinculado ao Exercise Medicine Research Institute sob orientação do Prof. Dr. Daniel A. Galvão, Prof. Dr. Dennis R. Taaffe, Prof. Dr. Robert U. Newton e Prof. Dra. Laurien M. Buffart, Licenciado em Educação Física pela Universidade Federal do Rio Grande do Sul (UFRGS), e mestre pelo Programa de Pós-Graduação em Ciências do Movimento Humano (PPGCMH/UFRGS) na mesma instituição sob orientação do Prof. Dr. Ronei Silveira Pinto 

Alice Aparecida Rodrigues Ferreira Francisco, Maple Tree Cancer Alliance Brasil

Maple Tree Cancer Alliance Brazil, Sorocaba, SP, Brasil

Citas

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2021;71(3):209-49. doi: 10.3322/caac.21660

Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA). [Internet]. 2019 [cited 2021 Aug 3]. Estimativa 2020: incidência de câncer no Brasil. https://www.inca.gov.br/sites/ufu.sti.inca.local/files//media/document//estimativa-2020-incidencia-de-cancer-no-brasil.pdf

Kayl AE, Meyers CA. Side-effects of chemotherapy and quality of life in ovarian and breast cancer patients. Curr Opin Obstet Gynecol 2006;18(1):24-8. doi: 10.1097/01.gco.0000192996.20040.24

Curt GA, Breitbart W, Cella D, Groopman JE, Horning SJ, Itri LM, et al. Impact of cancer-related fatigue on the lives of patients: new findings from the Fatigue Coalition. Oncologist 2000;5(5):353-60. doi: 10.1634/theoncologist.5-5-353

Freedman RJ, Aziz N, Albanes D, Hartman T, Danforth D, Hill S, et al. Weight and body composition changes during and after adjuvant chemotherapy in women with breast cancer. J Clin Endocrinol Metab 2004;89(5):2248-53. doi: 10.1210/jc.2003-031874

Perez EA, Suman VJ, Davidson NE, Kaufman PA, Martino S, Dakhil SR, et al. Effect of doxorubicin plus cyclophosphamide on left ventricular ejection fraction in patients with breast cancer in the North Central Cancer Treatment Group N9831 Intergroup Adjuvant Trial. J Clin Oncol 2004;22(18):3700-4. doi: 10.1200/jco.2004.03.516

Rock CL, Doyle C, Demark-Wahnefried W, Meyerhardt J, Courneya KS, Schwartz AL, et al. Nutrition and physical activity guidelines for cancer survivors. CA Cancer J Clin 2012;62(4):243-74. doi: 10.3322/caac.21142

Rock CL, Thomson C, Gansler T, Gapstur SM, McCullough ML, Patel AV, et al. American Cancer Society guideline for diet and physical activity for cancer prevention. CA Cancer J Clin 2020;70(4):245-71. doi: 10.3322/caac.21591

Schmitz KH, Courneya KS, Matthews C, Demark-Wahnefried W, Galvao DA, Pinto BM, et al. American College of Sports Medicine roundtable on exercise guidelines for cancer survivors. Med Sci Sports Exerc 2010;42(7):1409-26. doi: 10.1249/MSS.0b013e3181e0c112

Campbell KL, Winters-Stone KM, Wiskemann J, May AM, Schwartz AL, Courneya KS, et al. Exercise guidelines for cancer survivors: Consensus statement from international multidisciplinary roundtable. Med Sci Sports Exerc 2019;51(11):2375-90. doi: 10.1249/MSS.0000000000002116

Patel AV, Friedenreich CM, Moore SC, Hayes SC, Silver JK, Campbell KL, et al. American College of Sports Medicine Roundtable Report on Physical Activity, Sedentary Behavior, and Cancer Prevention and Control. Med Sci Sports Exerc 2019;51(11):2391-402. doi: 10.1249/Mss.0000000000002117

Schmitz KH, Campbell AM, Stuiver MM, Pinto BM, Schwartz AL, Morris GS, et al. Exercise is medicine in oncology: Engaging clinicians to help patients move through cancer. CA Cancer J Clin 2019;69(6):468-84. doi: 10.3322/caac.21579

Hayes SC, Spence RR, Galvao DA, Newton RU. Australian Association for Exercise and Sport Science position stand: Optimising cancer outcomes through exercise. J Sci Med Sport 2009;12(4):428-34. doi: 10.1016/j.jsams.2009.03.002

Hayes SC, Newton RU, Spence RR, Galvao DA. The Exercise and Sports Science Australia position statement: Exercise medicine in cancer management. J Sci Med Sport 2019;22(11):1175-99. doi: 10.1016/j.jsams.2019.05.003

Pollan M, Casla-Barrio S, Alfaro J, Esteban C, Segui-Palmer MA, Lucia A, et al. Exercise and cancer: a position statement from the Spanish Society of Medical Oncology. Clin Transl Oncol 2020;22(10):1710-29. doi: 10.1007/s12094-020-02312-y

Friedenreich CM, Stone CR, Cheung WY, Hayes SC. Physical activity and mortality in cancer survivors: a systematic review and meta-analysis. JNCI Cancer Spectr 2020;4(1):pkz080. doi: 10.1093/jncics/pkz080

Courneya KS, Segal RJ, Mackey JR, Gelmon K, Reid RD, Friedenreich CM, et al. Effects of aerobic and resistance exercise in breast cancer patients receiving adjuvant chemotherapy: a multicenter randomized controlled trial. J Clin Oncol 2007;25(28):4396-404. doi: 10.1200/jco.2006.08.2024

Schmitz KH, Ahmed RL, Troxel A, Cheville A, Smith R, Lewis-Grant L, et al. Weight lifting in women with breast-cancer-related lymphedema. N Engl J Med 2009;361(7):664-73. doi: 10.1056/NEJMoa0810118

Buffart LM, Sweegers MG, May AM, Chinapaw MJ, van Vulpen JK, Newton RU, et al. Targeting exercise interventions to patients with cancer in need: an individual patient data meta-analysis. J Natl Cancer Inst 2018;110(11):1190-200. doi: 10.1093/jnci/djy161

Cramp F, Byron-Daniel J. Exercise for the management of cancer-related fatigue in adults. Cochrane Database Syst Rev 2012;11:Cd006145. doi: 10.1002/14651858.CD006145.pub3

Maginador G, Lixandrão ME, Bortolozo HI, Vechin FC, Sarian LO, Derchain S, et al. Aerobic exercise-induced changes in cardiorespiratory fitness in breast cancer patients receiving chemotherapy: a systematic review and meta-analysis. Cancers (Basel) 2020;12(8). doi: 10.3390/cancers12082240

McNeely ML, Campbell KL, Rowe BH, Klassen TP, Mackey JR, Courneya KS. Effects of exercise on breast cancer patients and survivors: a systematic review and meta-analysis. Cmaj 2006;175(1):34-41. doi: 10.1503/cmaj.051073

Scott JM, Zabor EC, Schwitzer E, Koelwyn GJ, Adams SC, Nilsen TS, et al. Efficacy of exercise therapy on cardiorespiratory fitness in patients with cancer: a systematic review and meta-analysis. J Clin Oncol 2018;36(22):2297-305. doi: 10.1200/jco.2017.77.5809

Sweegers MG, Altenburg TM, Brug J, May AM, van Vulpen JK, Aaronson NK, et al. Effects and moderators of exercise on muscle strength, muscle function and aerobic fitness in patients with cancer: a meta-analysis of individual patient data. Br J Sports Med 2019;53(13):812. doi: 10.1136/bjsports-2018-099191

Van Vulpen JK, Sweegers MG, Peeters PHM, Courneya KS, Newton RU, Aaronson NK, et al. Moderators of exercise effects on cancer-related fatigue: a meta-analysis of individual patient data. Med Sci Sports Exerc 2020;52(2):303-14. doi: 10.1249/mss.0000000000002154

Courneya KS, Segal RJ, McKenzie DC, Dong H, Gelmon K, Friedenreich CM, et al. Effects of exercise during adjuvant chemotherapy on breast cancer outcomes. Med Sci Sports Exerc 2014;46(9):1744-51. doi: 10.1249/mss.0000000000000297

Smets EM, Garssen B, Schuster-Uitterhoeve AL, Haes JC. Fatigue in cancer patients. Br J Cancer 1993;68(2):220-4. doi: 10.1038/bjc.1993.319

Bower JE, Ganz PA, Desmond KA, Rowland JH, Meyerowitz BE, Belin TR. Fatigue in breast cancer survivors: occurrence, correlates, and impact on quality of life. J Clin Oncol 2000;18(4):743-53. doi: 10.1200/jco.2000.18.4.743

Ganz PA, Bower JE. Cancer related fatigue: a focus on breast cancer and Hodgkin's disease survivors. Acta Oncol 2007;46(4):474-9. doi: 10.1080/02841860701367845

Bardwell WA, Ancoli-Israel S. Breast cancer and fatigue. Sleep Med Clin 2008;3(1):61-71. doi: 10.1016/j.jsmc.2007.10.011

Bower JE. Cancer-related fatigue--mechanisms, risk factors, and treatments. Nat Rev Clin Oncol 2014;11(10):597-609. doi: 10.1038/nrclinonc.2014.127

Network NCC. NCCN guidelines for supportive care: Cancer-related fatigue. NCCN [Internet]. Version 1, January 17, 2018 [cited 2021 Aug 3]. Available from: https://www.nccn.org/guidelines/category_1#supportive

Hilfiker R, Meichtry A, Eicher M, Nilsson Balfe L, Knols RH, Verra ML, et al. Exercise and other non-pharmaceutical interventions for cancer-related fatigue in patients during or after cancer treatment: a systematic review incorporating an indirect-comparisons meta-analysis. Br J Sports Med 2018;52(10):651-8. doi: 10.1136/bjsports-2016-096422

Hiensch AE, Mijwel S, Bargiela D, Wengström Y, May AM, Rundqvist H. Inflammation mediates exercise effects on fatigue in patients with breast cancer. Med Sci Sports Exerc 2021;53(3):496-504. doi: 10.1249/mss.0000000000002490

Adams SC, Iyengar NM, Scott JM, Jones LW. Exercise implementation in oncology: one size does not fit all. J Clin Oncol 2018;36(9):925-6. doi: 10.1200/jco.2017.76.2906

Newton RU, Taaffe DR, Chambers SK, Spry N, Galvão DA. Effective exercise interventions for patients and survivors of cancer should be supervised, targeted, and prescribed with referrals from oncologists and general physicians. J Clin Oncol 2018;36(9):927-8. doi: 10.1200/jco.2017.76.7400

Newton RU, Taaffe DR, Galvao DA. Clinical Oncology Society of Australia position statement on exercise in cancer care. Med J Aust 2019;210(1):54-.54.e1. doi: 10.5694/mja2.12043

Courneya KS, McKenzie DC, Mackey JR, Gelmon K, Reid RD, Friedenreich CM, et al. Moderators of the effects of exercise training in breast cancer patients receiving chemotherapy: a randomized controlled trial. Cancer 2008;112(8):1845-53. doi: 10.1002/cncr.23379

Courneya KS, McKenzie DC, Mackey JR, Gelmon K, Friedenreich CM, Yasui Y, et al. Effects of exercise dose and type during breast cancer chemotherapy: multicenter randomized trial. J Natl Cancer Inst 2013;105(23):1821-32. doi: 10.1093/jnci/djt297

Mijwel S, Backman M, Bolam KA, Jervaeus A, Sundberg CJ, Margolin S, et al. Adding high-intensity interval training to conventional training modalities: optimizing health-related outcomes during chemotherapy for breast cancer: the OptiTrain randomized controlled trial. Breast Cancer Res Treat 2018;168(1):79-93. doi: 10.1007/s10549-017-4571-3

Bender CM, Sereika SM, Gentry AL, Duquette JE, Casillo FE, Marsland A, et al. Physical activity, cardiorespiratory fitness, and cognitive function in postmenopausal women with breast cancer. Support Care Cancer 2020;29(7):3743-52. doi: 10.1007/s00520-020-05865-4

Lakoski SG, Barlow CE, Koelwyn GJ, Hornsby WE, Hernandez J, Defina LF, et al. The influence of adjuvant therapy on cardiorespiratory fitness in early-stage breast cancer seven years after diagnosis: the Cooper Center Longitudinal Study. Breast Cancer Res Treat 2013;138(3):909-16. doi: 10.1007/s10549-013-2478-1

Jones LW, Courneya KS, Mackey JR, Muss HB, Pituskin EN, Scott JM, et al. Cardiopulmonary function and age-related decline across the breast cancer survivorship continuum. J Clin Oncol 2012;30(20):2530-7. doi: 10.1200/jco.2011.39.9014

Jones LW, Haykowsky MJ, Swartz JJ, Douglas PS, Mackey JR. Early breast cancer therapy and cardiovascular injury. J Am Coll Cardiol 2007;50(15):1435-41. doi: 10.1016/j.jacc.2007.06.037

Erikssen G, Liestøl K, Bjørnholt J, Thaulow E, Sandvik L, Erikssen J. Changes in physical fitness and changes in mortality. Lancet 1998;352(9130):759-62. doi: 10.1016/s0140-6736(98)02268-5

Kavanagh T, Mertens DJ, Hamm LF, Beyene J, Kennedy J, Corey P, et al. Peak oxygen intake and cardiac mortality in women referred for cardiac rehabilitation. J Am Coll Cardiol 2003;42(12):2139-43. doi: 10.1016/j.jacc.2003.07.028

Jones LW, Watson D, Herndon JE, 2nd, Eves ND, Haithcock BE, Loewen G, et al. Peak oxygen consumption and long-term all-cause mortality in nonsmall cell lung cancer. Cancer 2010;116(20):4825-32. doi: 10.1002/cncr.25396

Groarke JD, Payne DL, Claggett B, Mehra MR, Gong J, Caron J, et al. Association of post-diagnosis cardiorespiratory fitness with cause-specific mortality in cancer. Eur Heart J Qual Care Clin Outcomes 2020;6(4):315-22. doi: 10.1093/ehjqcco/qcaa015

Von Hoff DD, Layard MW, Basa P, Davis HL, Jr., Von Hoff AL, Rozencweig M, et al. Risk factors for doxorubicin-induced congestive heart failure. Ann Intern Med 1979;91(5):710-7. doi: 10.7326/0003-4819-91-5-710

Doyle JJ, Neugut AI, Jacobson JS, Grann VR, Hershman DL. Chemotherapy and cardiotoxicity in older breast cancer patients: a population-based study. J Clin Oncol 2005;23(34):8597-605. doi: 10.1200/jco.2005.02.5841

Trudeau M, Charbonneau F, Gelmon K, Laing K, Latreille J, Mackey J, et al. Selection of adjuvant chemotherapy for treatment of node-positive breast cancer. Lancet Oncol 2005;6(11):886-98. doi: 10.1016/s1470-2045(05)70424-1

Slamon D, Eiermann W, Robert N, Pienkowski T, Martin M, Press M, et al. Adjuvant trastuzumab in HER2-positive breast cancer. N Engl J Med 2011;365(14):1273-83. doi: 10.1056/NEJMoa0910383

Lavín-Pérez AM, Collado-Mateo D, Mayo X, Humphreys L, Liguori G, James Copeland R, et al. High-intensity exercise to improve cardiorespiratory fitness in cancer patients and survivors: A systematic review and meta-analysis. Scand J Med Sci Sports 2021;31(2):265-94. doi: 10.1111/sms.13861

Ansund J, Mijwel S, Bolam KA, Altena R, Wengström Y, Rullman E, et al. High intensity exercise during breast cancer chemotherapy - effects on long-term myocardial damage and physical capacity - data from the OptiTrain RCT. Cardiooncology 2021;7(1):7. doi: 10.1186/s40959-021-00091-1

Scharhag-Rosenberger F, Kuehl R, Klassen O, Schommer K, Schmidt ME, Ulrich CM, et al. Exercise training intensity prescription in breast cancer survivors: validity of current practice and specific recommendations. J Cancer Surviv 2015;9(4):612-9. doi: 10.1007/s11764-015-0437-z

van Waart H, Stuiver MM, van Harten WH, Geleijn E, Kieffer JM, Buffart LM, et al. Effect of low-intensity physical activity and moderate- to high-intensity physical exercise during adjuvant chemotherapy on physical fitness, fatigue, and chemotherapy completion rates: results of the paces randomized clinical trial. J Clin Oncol 2015;33(17):1918-27. doi: 10.1200/jco.2014.59.1081

Kampshoff CS, Jansen F, van Mechelen W, May AM, Brug J, Chinapaw MJ, et al. Determinants of exercise adherence and maintenance among cancer survivors: a systematic review. Int J Behav Nutr Phys Act 2014;11:80. doi: 10.1186/1479-5868-11-80

Kirkham AA, Bland KA, Zucker DS, Bovard J, Shenkier T, McKenzie DC, et al. "Chemotherapy-periodized" exercise to accommodate for cyclical variation in fatigue. Med Sci Sports Exerc 2020;52(2):278-86. doi: 10.1249/mss.0000000000002151

Scott JM, Iyengar NM, Nilsen TS, Michalski M, Thomas SM, Herndon J, 2nd, et al. Feasibility, safety, and efficacy of aerobic training in pretreated patients with metastatic breast cancer: A randomized controlled trial. Cancer 2018;124(12):2552-60. doi: 10.1002/cncr.31368

Borugian MJ, Sheps SB, Kim-Sing C, Van Patten C, Potter JD, Dunn B, et al. Insulin, macronutrient intake, and physical activity: are potential indicators of insulin resistance associated with mortality from breast cancer? Cancer Epidemiol Biomarkers Prev 2004;13(7):1163-72.

Holmes MD, Chen WY, Feskanich D, Kroenke CH, Colditz GA. Physical activity and survival after breast cancer diagnosis. Jama 2005;293(20):2479-86. doi: 10.1001/jama.293.20.2479

Irwin ML, Smith AW, McTiernan A, Ballard-Barbash R, Cronin K, Gilliland FD, et al. Influence of pre- and postdiagnosis physical activity on mortality in breast cancer survivors: the health, eating, activity, and lifestyle study. J Clin Oncol 2008;26(24):3958-64. doi: 10.1200/jco.2007.15.9822

Friedenreich CM, Gregory J, Kopciuk KA, Mackey JR, Courneya KS. Prospective cohort study of lifetime physical activity and breast cancer survival. Int J Cancer 2009;124(8):1954-62. doi: 10.1002/ijc.24155

Pike MC, Spicer DV, Dahmoush L, Press MF. Estrogens, progestogens, normal breast cell proliferation, and breast cancer risk. Epidemiol Rev 1993;15(1):17-35. doi: 10.1093/oxfordjournals.epirev.a036102

Key TJ, Allen NE, Verkasalo PK, Banks E. Energy balance and cancer: the role of sex hormones. Proc Nutr Soc 2001;60(1):81-9. doi: 10.1079/pns200068

Kaaks R, Lukanova A. Energy balance and cancer: the role of insulin and insulin-like growth factor-I. Proc Nutr Soc 2001;60(1):91-106. doi: 10.1079/pns200070

Okumura M, Yamamoto M, Sakuma H, Kojima T, Maruyama T, Jamali M, et al. Leptin and high glucose stimulate cell proliferation in MCF-7 human breast cancer cells: reciprocal involvement of PKC-alpha and PPAR expression. Biochim Biophys Acta 2002;1592(2):107-16. doi: 10.1016/s0167-4889(02)00276-8

Loucks AB. Energy availability, not body fatness, regulates reproductive function in women. Exerc Sport Sci Rev 2003;31(3):144-8. doi: 10.1097/00003677-200307000-00008

McTiernan A, Tworoger SS, Ulrich CM, Yasui Y, Irwin ML, Rajan KB, et al. Effect of exercise on serum estrogens in postmenopausal women: a 12-month randomized clinical trial. Cancer Res 2004;64(8):2923-8. doi: 10.1158/0008-5472.can-03-3393

Altman N, Krzywinski M. Association, correlation and causation. Nat Methods 2015;12(10):899-900. doi: 10.1038/nmeth.3587

Courneya KS, Booth CM, Gill S, O'Brien P, Vardy J, Friedenreich CM, et al. The Colon Health and Life-Long Exercise Change trial: a randomized trial of the National Cancer Institute of Canada Clinical Trials Group. Curr Oncol 2008;15(6):279-85. doi: 10.3747/co.v15i6.378

Wiskemann J, Kuehl R, Dreger P, Huber G, Kleindienst N, Ulrich CM, et al. Physical Exercise Training versus Relaxation in Allogeneic stem cell transplantation (PETRA Study) - Rationale and design of a randomized trial to evaluate a yearlong exercise intervention on overall survival and side-effects after allogeneic stem cell transplantation. BMC Cancer 2015;15:619. doi: 10.1186/s12885-015-1631-0

Newton RU, Kenfield SA, Hart NH, Chan JM, Courneya KS, Catto J, et al. Intense Exercise for Survival among Men with Metastatic Castrate-Resistant Prostate Cancer (INTERVAL-GAP4): a multicentre, randomized, controlled phase III study protocol. BMJ Open. 2018;8(5):e022899. doi: 10.1136/bmjopen-2018-022899

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2021-09-09