Influência da obesidade dinapênica sobre a inflamação e qualidade muscular em pessoas idosas longevas

Artigo original - e235475 - Publicado 27 de fevereiro de 2024

Autores

DOI:

https://doi.org/10.33233/rbfex.v23i1.5475

Palavras-chave:

força muscular, envelhecimento, obesidade, inflamação

Resumo

Introdução: O envelhecimento está associado à diminuição da força (dinapenia) e ao aumento da gordura corporal. Tanto a obesidade quanto a dinapenia influenciam negativamente a saúde dos longevos. A coexistência dessas duas variáveis, denominada obesidade dinapênica (OD), prejudica ainda mais a saúde da pessoa idosa. Objetivo: Verificar a influência da obesidade dinapênica na inflamação, desempenho físico e qualidade muscular em pessoas idosas longevas com e sem OD. Métodos: Foram incluídos 46 idosos longevos e coletados dados sociodemográficos, de força muscular, composição corporal, desempenho físico e citocinas. A amostra foi dividida em grupos OD e controle para comparar as variáveis. Resultados: O grupo OD apresentou maiores níveis de inflamação, níveis inferiores de força muscular absoluta de preensão manual e índice de qualidade muscular de campo do que o grupo controle, mas sem diferença no desempenho físico ou no índice de qualidade muscular laboratorial. Conclusão: Portanto, este estudo aponta a obesidade dinapênica como uma variável importante que deve ser avaliada e considerada em pessoas idosas longevas para prevenir possíveis desfechos adversos nessa população.

Biografia do Autor

Bruno Viana Rosa,

Departamento de Educação Física, Universidade Católica de Brasília (UCB), Brasília, DF, Brasil

Danielle Garcia, UCB

Departamento de Educação Física, Universidade Católica de Brasília (UCB), Brasília, DF, Brasil

Ivo Vieira de Sousa Neto, USP

Escola de Educação Física e Esporte, Universidade de São Paulo (USP), São Paulo, Brasil

Vicente Paulo Alves, UCB

Departamento de Gerontologia, Universidade Católica de Brasília (UCB), Brasília, DF, Brasil

Lidiane Renata Ferreira de Oliveira de Paiva, UCB

Departamento de Gerontologia, Universidade Católica de Brasília (UCB), Brasília, DF, Brasil

Karla Helena Coelho Vilaça Silva, UCB

Departamento de Gerontologia, Universidade Católica de Brasília (UCB), Brasília, DF, Brasil

Flávia Maria Campos de Abreu, UCB

Departamento de Gerontologia, Universidade Católica de Brasília (UCB), Brasília, DF, Brasil

Dahan da Cunha Nascimento, UCB

Departamento de Educação Física, Universidade Católica de Brasília (UCB), Brasília, DF, Brasil

Referências

Lee MM, Jebb SA, Oke J, Piernas C. Reference values for skeletal muscle mass and fat mass measured by bioelectrical impedance in 390 565 UK adults. J Cachexia, Sarcopenia Muscle. 2020;11(2). doi: 10.1002/jcsm.12523

Strugnell C, Dunstan DW, Magliano DJ, Zimmet PZ, Shaw JE, Daly RM. Influence of age and gender on fat mass, fat-free mass and skeletal muscle mass among Australian adults: the Australian diabetes, obesity and lifestyle study (AusDiab). J Nutr Health Aging. 2014;18(5). doi: 10.1007/s12603-014-0464-x

Stenholm S, Alley D, Bandinelli S, Griswold ME, Koskinen S, Rantanen T, et al. The effect of obesity combined with low muscle strength on decline in mobility in older persons: results from the InCHIANTI study. Int J Obes (Lond). 2009;33(6). doi: 10.1038/ijo.2009.62

Tieland M, Trouwborst I, Clark BC. Skeletal muscle performance and ageing. J Cachexia Sarcopenia Muscle. 2018;9(1). doi: 10.1002/jcsm.12238

Biltz NK, Collins KH, Shen KC, Schwartz K, Harris CA, Meyer GA. Infiltration of intramuscular adipose tissue impairs skeletal muscle contraction. J Physiol. 2020;598(13). doi: 10.1113/JP279595

Kragstrup TW, Kjaer M, Mackey AL. Structural, biochemical, cellular, and functional changes in skeletal muscle extracellular matrix with aging. Scand J Med Sci Sports. 2011;21(6). doi: 10.1111/j.1600-0838.2011.01377.x

Pérez-Campos Mayoral L, Matias-Cervantes CA, Pérez-Campos E, Romero Díaz C, Laguna Barrios LÁ, Pina Canseco MDS, et al. Associations of Dynapenic Obesity and Sarcopenic Obesity with the Risk of Complications in COVID-19. Int J Mol Sci. 2022;23(15). doi: 10.3390/ijms23158277

Máximo RO, Oliveira DC, Ramirez PC, Luiz MM, Souza AF, Delinocente MLB, et al. Combination of dynapenia and abdominal obesity affects long-term physical performance trajectories in older adults: sex differences. Am J Clin Nutr. 2022;115(5). doi: 10.1093/ajcn/nqac023

Clark BC, Manini TM. What is dynapenia? Nutrition. 2012;28(5). doi: 10.1016/j.nut.2011.12.002

Mitchell WK, Williams J, Atherton P, Larvin M, Lund J, Narici M. Sarcopenia, dynapenia, and the impact of advancing age on human skeletal muscle size and strength; a quantitative review. Front Physiol. 2012;3. doi: 10.3389/fphys.2012.00260

Yang M, Ding X, Luo L, Hao Q, Dong B. Disability associated with obesity, dynapenia and dynapenic-obesity in Chinese older adults. J Am Med Dir Assoc. 2014;15(2). doi: 10.1016/j.jamda.2013.10.009

Bektas A, Schurman SH, Sen R, Ferrucci L. Aging, inflammation and the environment. Exp Gerontol. 2018;105:10-18. doi: 10.1016/j.exger.2017.12.015.

Franceschi C, Campisi J. Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. J Gerontol A Biol Sci Med Sci. The journals of gerontology Series A, Biological sciences and medical sciences. 2014;69(Suppl1):S4-9. doi: 10.1093/gerona/glu057

Minciullo PL, Catalano A, Mandraffino G, Casciaro M, Crucitti A, Maltese G, Morabito N, Lasco A, Gangemi S, Basile G. Inflammaging and anti-inflammaging: the role of cytokines in extreme longevity. Arch Immunol Ther Exp (Warsz). 2016;64(2):111-26. doi: 10.1007/s00005-015-0377-3

Frasca D, Blomberg BB, Paganelli R. Aging, obesity, and inflammatory age-related diseases. Front Immunol. 2017;8:1745. doi: 10.3389/fimmu.2017.01745

Tuttle CSL, Thang LAN, Maier AB. Markers of inflammation and their association with muscle strength and mass: A systematic review and meta-analysis. Ageing Res Rev. 2020;64:101185. doi: 10.1016/j.arr.2020

Sartori R, Romanello V, Sandri M. Mechanisms of muscle atrophy and hypertrophy: implications in health and disease. Nat Commun. 2021;12(1):330. doi: 10.1038/s41467-020-20123-1

Antunes BM, Rossi FE, Inoue DS, Neto JCR, Lira FS. Immunometabolism and exercise: new avenues. Motricidade. 2017;13(1):85-89. doi: 10.6063/motricidade.7941

Flegal KM, Kit BK, Orpana H, Graubard BI. Association of all-cause mortality with overweight and obesity using standard body mass index categories: a systematic review and meta-analysis. JAMA. 2013;309(1):71-82. doi: 10.1001/jama.2012.113905

Celis-Morales CA, Welsh P, Lyall DM, Steell L, Petermann F, Anderson J, et al. Associations of grip strength with cardiovascular, respiratory, and cancer outcomes and all cause mortality: prospective cohort study of half a million UK Biobank participants. BMJ. 2018;361:k1651. doi: 10.1136/bmj.k1651

Legrand D, Adriaensen W, Vaes B, Matheï C, Wallemacq P, Degryse J. The relationship between grip strength and muscle mass (MM), inflammatory biomarkers and physical performance in community-dwelling very old persons. Arch Gerontol Geriatr. 2013;57(3):345-51. doi: 10.1016/j.archger.2013.06.003

Paranhos Amorim DN, Nascimento DDC, Stone W, Alves VP, Coelho Vilaça E Silva KH. Body composition and functional performance of older adults. Osteoporos Sarcopenia. 2022;8(2):86-91. doi: 10.1016/j.afos.2022.04.002

Gadelha AB, Neri SGR, Vainshelboim B, Ferreira AP, Lima RM. Dynapenic abdominal obesity and the incidence of falls in older women: a prospective study. Aging Clin Exp Res. 2020;32(7):1263-70. doi: 10.1007/s40520-019-01318-z

Rossi AP, Bianchi L, Volpato S, Bandinelli S, Guralnik J, Zamboni M, et al. Dynapenic Abdominal Obesity as a Predictor of Worsening Disability, Hospitalization, and Mortality in Older Adults: Results From the InCHIANTI Study. J Gerontol A Biol Sci Med Sci. 2017;72(8):1098-104. doi: 10.1093/gerona/glw203

Ribeiro JC, Duarte JG, Gomes GAO, Costa-Guarisco LP, de Jesus ITM, Nascimento CMC, et al. Associations between inflammatory markers and muscle strength in older adults according to the presence or absence of obesity. Exp Gerontol. 2021;151:111409. doi: 10.1016/j.exger.2021.111409

Corrêa HL, Rosa TDS, Dutra MT, Sales MM, Noll M, Deus LA, et al. Association between dynapenic abdominal obesity and inflammatory profile in diabetic older community-dwelling patients with end-stage renal disease. Exp Gerontol. 2021;146:111243. doi: 10.1016/j.exger.2021.111243

Roberts HC, Denison HJ, Martin HJ, Patel HP, Syddall H, Cooper C, et al. A review of the measurement of grip strength in clinical and epidemiological studies: towards a standardised approach. Age Ageing. 2011;40(4):423-9. doi: 10.1093/ageing/afr051

Hiol AN, von Hurst PR, Conlon CA, Mugridge O, Beck KL. Body composition associations with muscle strength in older adults living in Auckland, New Zealand. PLoS One. 2021;16(5):e0250439. doi: 10.1371/journal.pone.0250439

Murai J, Nishizawa H, Otsuka A, Fukuda S, Tanaka Y, Nagao H, et al. Low muscle quality in Japanese type 2 diabetic patients with visceral fat accumulation. Cardiovasc Diabetol. 2018;17(1):112. doi: 10.1186/s12933-018-0755-3.

Barbat-Artigas S, Rolland Y, Cesari M, Abellan van Kan G, Vellas B, Aubertin-Leheudre M. Clinical relevance of different muscle strength indexes and functional impairment in women aged 75 years and older. J Gerontol A Biol Sci Med Sci. 2013;68(7):811-9. doi: 10.1093/gerona/gls254

Nascimento DDC, Prestes J, de Sousa Diniz J, Beal PR, Alves VP, Stone W, et al. Comparison of field- and laboratory-based estimates of muscle quality index between octogenarians and young older adults: an observational study. J Exerc Rehabil. 2020;16(5):458-66. doi: 10.12965/jer.2040668.334

Melo GLR, Moraes MR, Nascimento EF, Boato EM, Beal FLR, Stone W, et al. Field-based versus laboratory-based estimates of muscle quality index in adolescents with and without Down syndrome. J Intellect Disabil Res. 2022;66(12):1000-8. doi: 10.1111/jir.12959

Cruz-Jentoft AJ, Bahat G, Bauer J, Boirie Y, Bruyere O, Cederholm T, et al. Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing. 2019;48(1):16-31. doi: 10.1093/ageing/afy169

Batsis JA, Villareal DT. Sarcopenic obesity in older adults: aetiology, epidemiology and treatment strategies. Nat Rev Endocrinol. 2018;14(9):513-37. doi: 10.1038/s41574-018-0062-9

Nakano MM, Otonari TS, Takara KS, Carmo CM, Tanaka C. Physical performance, balance, mobility, and muscle strength decline at different rates in elderly people. J Phys Ther Sci. 2014;26(4):583-6. doi: 10.1589/jpts.26.583.

Faul F, Erdfelder E, Lang A-G, Buchner A. G* Power 3: A flexible statistical power analysis program for the social, behavioral, and biomedical sciences. J Behavior research methods. 2007;39(2):175-91. doi: 10.3758/bf03193146

Santos Morais Junior G, Ignacio Valenzuela Perez D, Cecília Tonet-Furioso A, Gomes L, Coelho Vilaça KH, Paulo Alves V, et al. Circulating interleukin-6 (but not other immune mediators) associates with criteria for fried's frailty among very old adults. J Aging Res. 2020;2020:6831791. doi: 10.1155/2020/6831791

Valenzuela PL, Maffiuletti NA, Tringali G, De Col A, Sartorio A. Obesity-associated poor muscle quality: prevalence and association with age, sex, and body mass index. BMC Musculoskelet Disord. 2020;21(1):200. doi: 10.1186/s12891-020-03228-y

Fragala MS, Kenny AM, Kuchel GA. Muscle quality in aging: a multi-dimensional approach to muscle functioning with applications for treatment. Sports Med. 2015;45(5):641-58. doi: 10.1007/s40279-015-0305-z

Santos EPRD, Silva CFR, Ohara DG, Matos AP, Pinto ACPN, Pegorari MS. Short Physical Performance Battery (SPPB) score as a discriminator of dynapenic abdominal obesity among community-dwelling older adults. Geriatr Nurs. 2021;42(2):467-72. doi: 10.1016/j.gerinurse.2021.02.016

Publicado

2024-02-27 — Atualizado em 2024-03-18

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