Asthma as a risk factor for COVID-19 infection in children: an integrative review

Authors

DOI:

https://doi.org/10.33233/eb.v22i4.5284

Keywords:

asthma, covid-19, child, risk factors

Abstract

Introduction: The world is experiencing a reality caused by the SARS-Cov-2 pandemic and its variants. One of the aggravating factors for a patient with COVID-19 is the presence of some comorbidity, including asthma. Objective: Analyze the studies conducted on asthma and COVID-19 in children, describe the evidence found so far. Method: It consists of an integrative literature review, with a guiding question elaborated through the PICO strategy. Results: 18 articles made up the final sample as they met the inclusion criteria and were derived from the Medline database via Pubmed. Conclusion: The understanding of the relationship between SARS-CoV-2 infection and asthma in pediatrics is still incipient, however the evidence suggests that it is not a risk factor for infection and may still be a protective factor. However, extensive researches with larger samples is essential for a better analysis.

Author Biographies

Vânia Chagas da Costa, UPE

Professora Assistente, Universidade de Pernambuco, Recife, PE, Brasil

Manoela Pires Barreto, UPE

Enfermeira, Universidade de Pernambuco, Recife, PE, Brasil

Maria Clara Cordeiro Andrade, UPE

Enfermeira, Universidade de Pernambuco, Recife, PE, Brasil

Sabrina Mayara da Silva Lopes, UPE

Enfermeira, Universidade de Pernambuco, Recife, PE, Brasil

Monique Maria de Lima Nascimento, UPE

Enfermeira Residente, Universidade de Pernambuco, Recife, PE, Brasil

Fernanda Portela de Carvalho, UPE

Enfermeira Residente, Universidade de Pernambuco, Recife, PE, Brasil

Ana Célia Oliveira dos Santos, UPE

Professora Livre-docente, Universidade de Pernambuco, Recife, PE, Brasil

References

Strabelli TMV, Uip DE. COVID-19 and the Heart. Arq Bras Cardiol. 2020 Apr;114(4):598-600. English, Portuguese. doi: 10.36660/abc.20200209

Ruan Q, Yang K, Wang W, Jiang L, Song J. Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China. Intensive Care Med. 2020;46(5):846-8. doi: 10.1007/s00134-020-05991-x

WHO Coronavirus Disease (COVID-19) Dashboard [Internet]. World Health Organization. 2022. [citado 2022 Set 12]. Disponível em: https://covid19.who.int/

Terry PD, Heidel RE, Dhand R. Asthma in adult patients with COVID-19. Prevalence and Risk of Severe Disease. Am J Respir Crit Care Med. 2021;203(7):893-905. doi: 10.1164/rccm.202008-3266OC

Global Initiative for Asthma. Global Strategy for Asthma Management and Prevention, 2022 [Internet]. [citado 2022 Set 12]. Disponível em: www.ginasthma.org

Swartz MK, Meadows-Oliver M. Clinical outcomes of a pediatric asthma outreach program. J Nurse Pract. 2019;15(6):e119-e121. doi: 10.1016/j.nurpra.2019.01.012

Galvão CM, Sawada NO, Trevizan MA. Revisão sistemática: recurso que proporciona a incorporação das evidências na prática da enfermagem. Rev Latino-Am Enfermagem. 2004;12(3):549-56. doi: 10.1590/S0104-11692004000300014

Silveira RCCP. O cuidado de enfermagem e o cateter de Hickman: a busca de evidências [Dissertação]. Ribeirão Preto: Universidade de São Paulo, Escola de Enfermagem de Ribeirão Preto; 2005.

Methley AM, Campbell S, Chew-Graham C, McNally R, Cheraghi-Sohi S. PICO, PICOS and SPIDER: a comparison study of specificity and sensitivity in three search tools for qualitative systematic reviews. BMC Health Serv Res. 2014;14:579. doi: 10.1186/s12913-014-0579-0

Moher D, Shamseer L, Clark M. Ghersi D, Liberati A, Petticrew M, et al. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Syst Rev. 2015;4(1). doi: 10.1186/2046-4053-4-1

Castro-Rodriguez JA, Forno E. Asthma and COVID-19 in children: A systematic review and call for data. Pediatr Pulmonol. 2020;55(9):2412-18. doi: 10.1002/ppul.24909

Boechat JL, Wandalsen GF, Kuschnir FC, Delgado L. COVID-19 and pediatric asthma: clinical and management challenges. Int J Environ Res. Public Health 2021;18(3):1093. doi: 10.3390/ijerph18031093

Chatziparasidis G, Kantar A. COVID-19 in children with asthma. Lung. 2021;199(1):7-12. doi: 10.1007/s00408-021-00419-9

Abrams EM, Shaker M, Greenhawt M. School attendance, asthma risk, and COVID-19 in children. J Allergy Clin Immunol Pract. 2021;9(6):2145-50. doi: 10.1016/j.jaip.2021.03.006

Tagarro A, Cobos-Carrascosa E, Villaverde S, Sanz-Santaeufemia FJ, Grasa C, Soriano-Arandes A, et al. Clinical spectrum of COVID-19 and risk factors associated with severity in Spanish children. Eur J Pediatr. 2022;181(3):1105-15. doi: 10.1007/s00431-021-04306-6

Brough HA, Kalayci O, Sediva A, Untersmayr E, Munblit D, Del Rio PR, et al. Managing childhood allergies and immunodeficiencies during respiratory virus epidemics – The 2020 COVID-19 pandemic: A statement from the EAACI-section on pediatrics. Pediatr Allergy Immunol. 2020;31:442-8. doi: 10.1111/pai.13262

Farzan S, Rai S, Cerise J, Bernstein S, Coscia G, Hirsch JS, et al. Asthma and COVID-19: An early inpatient and outpatient experience at a US children's hospital. Pediatr Pulmonol. 2021;56(8):2522-2529. doi: 10.1002/ppul.25514

Kompaniyets L, Agathis NT, Nelson JM, Preston LE, Ko JY, Belay B, et al. Underlying medical conditions associated with severe COVID-19 illness among children. JAMA Netw Open. 2021;4(6):e2111182. doi: 10.1001/jamanetworkopen.2021.11182

Gaietto K, Freeman MC, DiCicco LA, Rauenswinter S, Squire JR, Aldewereld Z, et al. Asthma as a risk factor for hospitalization in children with COVID-19: A nested case-control study. Pediatr Allergy Immunol. 2022;33(1):e13696. doi: 10.1111/pai.13696

Beken B, Ozturk GK, Aygun FD, Aydogmus C, Akar HH. Asthma and allergic diseases are not risk factors for hospitalization in children with coronavirus disease 2019. Ann Allergy Asthma Immunol. 2021 May;126(5):569-75. doi: 10.1016/j.anai.2021.01.018

Amat F, Delaisi B, Labbé JP, Leonardi J, Houdouin V. Asthma may not be a risk factor for severe COVID-19 in children. J Allergy Clin Immunol Pract. 2021;9(6):2478-9. doi: 10.1016/j.jaip.2021.03.046

Brindisi G, Zicari AM, Parisi GF, Diaferio L, Indolfi C, Marchese G, et al. Prevalence of COVID-19 in children affected by allergic rhinoconjunctivitis and asthma: results from the second “SIAIP rhinosinusitis and conjunctivitis committee” survey. Ital J Pediatr. 2022;48(1). doi: 10.1186/s13052-021-01198-y

Sousa BLA, Brentani A, Ribeiro CCC, Dolhnikoff M, Grisi SJFE, Ferrer APS, et al. Non-communicable diseases, sociodemographic vulnerability and the risk of mortality in hospitalised children and adolescents with COVID-19 in Brazil: a cross-sectional observational study. BMJ Open 2021;11:e050724. doi: 10.1136/bmjopen-2021-050724

Bandi S, Nevid MZ, Mahdavinia M. African American children are at higher risk of COVID-19 infection. Pediatr Allergy Immunol. 2020 Oct;31(7):861-4. doi: 10.1111/pai.13298

Kara AA, Böncüoğlu E, Kıymet E, Arıkan KÖ, Şahinkaya Ş, Düzgöl M, et al. Evaluation of predictors of severe-moderate COVID-19 infections at children: A review of 292 children. J Med Virol. 2021;93(12):6634-40. doi: 10.1002/jmv.27237

Rai N, Cornett JA, Zachariah P, Quittell L, Lovinsky-Desir S. Severe respiratory viral infections in children with history of asymptomatic or mild COVID-19. Pediatric Pulmonology. 2022; 57:361-6. doi: 10.1002/ppul.25752

Ibrahim LF, Tosif S, McNab S, Hall S, Lee HJ, Lewena S, et al. SARS-CoV-2 testing and outcomes in the first 30 days after the first case of COVID-19 at an Australian children's hospital. Emerg Med Australas. 2020;32(5):801-8. doi: 10.1111/1742-6723.13550

Abrams EM, Szefler SJ. Managing Asthma during Coronavirus Disease-2019: An Example for Other Chronic Conditions in Children and Adolescents. J Pediatr. 2020;222:221-6. doi: 10.1016/j.jpeds.2020.04.049

Published

2023-09-13