Correlation between intestinal microbiota and neurological disorders

Authors

DOI:

https://doi.org/10.33233/eb.v22i6.5570

Keywords:

Gut-brain axis, Humoral influence of microbiota, Neurological disorders

Abstract

The intestinal microbiota, composed of a diversity of microorganisms, plays a crucial role in digestion, nutrient absorption, and the overall health of the host. Its composition varies based on individual factors such as diet, age, genetics, and environment. Despite the understanding of the intestines' influence on hormone production like serotonin, the effects of microbiota alterations on the nervous system remain poorly elucidated. This article explores recent scientific findings on this gut-brain axis, emphasizing various studies that investigated the effects of intestinal microbiota on behavior and the central nervous system.

Author Biographies

Clara de Almeida e Araujo Leite , UNESA

Discente de Medicina - UNESA, Rio de Janeiro, RJ, Brasil

Juan Pablo Lemos dos Santos , UNIG

Acadêmico de medicina Universidade Iguaçu, Rio de Janeiro, RJ, Brasil

Luciana Armada, UNIG

Professora da Graduação e Pós-Graduação em Odontologia, Universidade Iguaçu, RJ, Brasil

Marco Antonio Araujo Leite, UFF

Serviço de Neurologia, Universidade Federal Fluminense, Niteroí, RJ, Brasil

Catarine Torquato Barcellos , UNESA

Universidade Estacio de Sá, Rio de Janeiro, RJ, Brasil

Thiago de Mello Tavares, UNC

Universidade do Contestado, Mafra, SC, Brasil

Marco Orsini, UNIG

Médico, Professor do Programa de Mestrado em Vigilância em Saúde - UNIG, Universidade Federal do Rio de Janeiro - IPUB - UFRJ, RJ, Brasil

References

Lanxiang Liu, Haiyang Wang, Xueyi Chen, Peng Xie. Gut microbiota: a new insight into neurological diseases. Chin Med J. 2023;136(11):1261-77. doi: 10.1097/CM9.0000000000002212

Murakami T, Kamada K, Mizushima K, Higashimura Y, Katada K, Uchiyama K, et al. Changes in intestinal motility and gut microbiota composition in a rat stress model. Digestion. 2017;95(1):55-60. doi: 10.1159/000452364

Cryan JF, O’Riordan KJ, Cowan CSM, Sandhu KV, Bastiaanssen TFS, Boehme M, et al. The microbiota-gut-brain axis. Physiol Rev. 2019;99(4):1877-2013. doi: 10.1152/physrev.00018.2018

Faulin T, Estadella D. Alzheimer’s disease and its relationship with the microbiota-gut-brain axis. Arq gastroenterol. 2023.;60(1). doi: 10.1590/S0004-2803.202301000-17

Nannan Li, Qi Wang, Yan Wang, Anji Sun, Yiwei Lin, Ye Jin, Xiaobai Li, et al.. Fecal microbiota transplantation from chronic unpredictable mild stress mice donors affects anxiety-like and depression-like behavior in recipient mice via the gut microbiota-inflammation-brain axis. Stress. 2019;22(5):592-602. doi: 10.1080/10253890.2019.1617267

Zheng P, Zeng B, Liu M, Chen J, Pan J, Han Y, et al. The gut microbiome from patients with schizophrenia modulates the glutamate-glutamine-GABA cycle and schizophrenia-relevant behaviors in mice. Sci Adv. 2019;5(2):eaau8317. doi: 10.1126/sciadv.aau8317

Mejía-Granados DM, Villasana-Salazar B, Coan AC, Balthazar MLF, Godoi AB, Canto AM, et al. Gut microbiome in neuropsychiatric disorders. Arq Neuro-Psychiatr. 2022;80(2). doi: 10.1590/0004-282X-ANP-2021-0052

Aho VTE, Pereira PAB, Voutilainen S, Paulin L, Pekkonen E, Auvinen P, et al. Gut microbiota in Parkinson's disease: Temporal stability and relations to disease progression. EBioMedicine. 2019;44:691-707. doi: 10.1016/j.ebiom.2019.05.064

Glover ME, Cohen JL, Singer JR, Sabbagh MN, Rainville JR, Hyland MT, et al. Examining the role of microbiota in emotional behavior: antibiotic treatment exacerbates anxiety in high anxiety-prone male rats. Neuroscience. 2021;459:179-97. doi: 10.1016/j.neuroscience.2021.01.030

Ping Liu, Li Wu, et al. Altered microbiomes distinguish Alzheimer’s disease from amnestic mild cognitive impairment and health in a Chinese cohort. Brain, Behavior, and Immunity 2019;80:633-43. doi: 10.1016/j.bbi.2019.05.008

Vogt NM, Kerby RL, et al. Gut microbiome alterations in Alzheimer’s disease. Scientific Reports. 2017;7:13537. [acesso em 25 ago 2023]; Disponível em: https://www.nature.com/articles/s41598-017-13601-y

Chunxiao Li, Li Cui et al. Gut microbiota differs between parkinson’s disease patients and healthy controls in Northeast China. Front Mol Neurosci. 2019;12. doi: 10.3389/fnmol.2019.00171

Arora K, Green M, Prakash S. The microbiome and Alzheimer's Disease: potential and limitations of prebiotic, synbiotic, and probiotic formulations. Front Bioeng Biotechnol. 2020;8:537847. doi: 10.3389/fbioe.2020.537847

Naomi R, Embong H, Othman F, Ghazi HF, Maruthey N and Bahari H. Probiotics for Alzheimer's disease: a systematic review. Nutrients. 2021;14(1):20. doi: 10.3390/nu14010020

Cekanaviciut E, Yoo BB, Runia TF, Baranzini SE, et al. Gut bacteria from multiple sclerosis patients modulate human T cells and exacerbate symptoms in mouse models. PNAS. 2017;114(40):10713-18. doi: 10.1073/pnas.1711235114

Cantarel BL, Waubant E, et al. Gut microbiota in multiple sclerosis: possible influence of immunomodulators. Journal of Investigating Medicine. 2015 ;63(5):729-34. doi: 10.1097/JIM.0000000000000192

Keshavarzian A, Green SJ, et al. Colonic bacterial composition in Parkinson's disease. Movement Disorders. 2015;10:1351-60. doi: 10.1002/mds.26307

Aho VTE, Houser MC, at al. Relationships of gut microbiota, short-chain fatty acids, inflammation, and the gut barrier in Parkinson’s disease. Molecular Neurodegeneration. 2021;16:6. doi: 10.1186/s13024-021-00427-6

Na Li, Xingcui Wang, et al. Change of intestinal microbiota in cerebral ischemic stroke patients. BMC Microbiology. 2019;19:191. doi: 10.1186/s12866-019-1552-1

Kihyun Lee, Namil Kim at al. Gut bacterial dysbiosis in children with intractable epilepsy. J Clin Med. 2021;10(5). doi: 10.3390/jcm10010005

Anjiao Peng, Xiangmiao Qiu, et al. Altered composition of the gut microbiome in patients with drug-resistant epilepsy. Epilepsy Research. 2018;147:102-07. doi: 10.1016/j.eplepsyres.2018.09.013

Published

2024-01-28