Estudo da emissão de luz por diodo infravermelho na dor neuropática em ratos
DOI:
https://doi.org/10.33233/fb.v14i4.404Abstract
Introdução: A lesão nervosa periférica pode causar alterações funcionais tanto sensitivas quanto motoras, podendo promover importantes comprometimentos, especialmente a dor neuropática. Dentre os vários tratamentos propostos está o emprego da luz monocromática de baixa intensidade, como o diodo de emissão de luz (LED). Objetivo: Avaliar o efeito analgésico do LED no espectro infravermelho em modelo experimental de dor neuropática por constrição do nervo ciático em ratos. Material e métodos: Foram utilizados 24 ratos machos Wistar, randomizados em 4 grupos (n = 6). Grupo I: animais neuropáticos e tratados com LED; grupo II: animais neuropáticos e tratados com o LED desligado (placebo); grupo III: animais Sham e tratados com LED; grupo IV: animais Sham e tratados com LED desligado (placebo). Para avaliar a eficácia do tratamento, foram empregados parâmetros de nocicepção como alodínia mecânica estática, dinâmica e térmica ao frio; hiperalgesia térmica ao calor e nocicepção espontânea. Resultados: Os animais neuropáticos desenvolveram alodínia e hiperalgesia ao estímulo mecânico, térmico e nocicepção espontânea em 7 dias (Tempo 0) contados a partir da indução da neuropatia, mantendo essas manifestações até o 14º dia. Conclusão: O tratamento contínuo com LED no espectro infravermelho promoveu efeito analgésico em um modelo experimental de dor neuropática em ratos. Os resultados obtidos neste estudo sugerem que esse recurso físico pode ser utilizado no tratamento de pacientes com dor neuropática.
Palavras-chave: dor, neuropatia, diodo de emissão de luz.
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