Neuromuscular changes in patients with COVID-19

Authors

DOI:

https://doi.org/10.33233/fb.v22i3.4708

Keywords:

COVID-19; SARS-CoV-2; neuromuscular diseases

Abstract

Introduction: In December 2019, a new coronavírus called SARS-CoV-2 appeared in China. The disease named COVID-19 quickly became a pandemic. It is known that, in the long term, patients in the most acute period of the disease, may present syndromes that cause fatigue, pain and dyspnea. Objective: The study aimed to carry out an integrative review about neuromuscular changes in patients with COVID-19. Methods: The study took place in October and November 2020, without limitation of year and language. The following databases were used: PubMed, Scientific Electronic Library online (SciELO), Literatura Latino-Americana e do Caribe em Ciência da Saúde (Lilacs), and Google Scholar. Results: 19,316 studies were identified, 15 of which were selected after reading titles and abstracts. After removing duplicates, 13 articles were read in full. Finally, 7 articles were selected after excluding those that did not meet the eligibility criteria. Study participants were between 42 and 90 years old, all with COVID-19 and associated neuromuscular pathologies: neuromuscular dysfunction, myalgia, Guillain-Barré syndrome, myopathy and general muscle weakness. The highest pain index reported was in the musculoskeletal system (upper, lower limb and lumbar region). Conclusion: COVID-19 can lead to neuromuscular complications.

Author Biographies

Evelyne Pires de Holanda, FACOTTUR

Graduanda em Fisioterapia pela Faculdade de Comunicação Tecnologia e Turismo de Olinda (FACOTTUR), Olinda/PE

Thays Barreto Januário Chaves de Figueirêdo, FACOTTUR

Graduanda em Fisioterapia pela Faculdade de Comunicação Tecnologia e Turismo de Olinda (FACOTTUR), Olinda/PE

Nataly Belfort Ferreira Alves, FACOTTUR

Graduanda em Fisioterapia pela Faculdade de Comunicação Tecnologia e Turismo de Olinda (FACOTTUR), Olinda/PE

Eulaine Souza de Aragão, FACOTTUR

Graduanda em Fisioterapia pela Faculdade de Comunicação Tecnologia e Turismo de Olinda (FACOTTUR), Olinda/PE

Diana Babini Lapa de Albuquerque Britto, UFPE

Fonoaudióloga, professora substituta da Universidade Federal de Pernambuco (UFPE) e professora do curso de Fisioterapia pela Faculdade de Comunicação Tecnologia e Turismo de Olinda (FACOTTUR), Olinda/PE

References

Cavalcante JR, Santos ACC, Bremm JM, Lobo AP, Macário EM, Oliveira WK, et al. Covid-19 no Brasil: evolução da epidemia até a semana epidemiológica 20 de 2020. Epidemiol Serv Saúde 2020;29(4):e2020376. doi: 10.5123/s1679-49742020000400010

Phelan AL, Katz R, Gostin LO. The novel coronavirus originating in Wuhan. China: Challenges for Global Health Governance. JAMA 2020;323(8):709-10. doi: 10.1001/jama.2020.1097

Britto DBLA, Rocha MFB, Costa LFSB, Costa Filho CFB, Tenorio BM, Maia CM, et al. Achados neurológicos, alterações sensoriais da função olfativa, gustativa e auditiva em pacientes com Covid-19: uma revisão literária. Revista Eletrônica Acervo Saúde 2020;46(e4174):1-8. doi: 10.25248/reas.e4174.2020

Huang C, Wang Y, Wang X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. The Lancet 2020;395(10223):497-506. doi: 10.1016/S0140-6736(20)30183-5

Wu Z, Mcgoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72314 cases from the Chinese center for disease control and prevention. JAMA 2020;323(13):1239-42. doi: 10.1001/jama.2020.2648

Kwalski LP, Sanabria A, Ridge JA, Tong W, Bree R, Rinaldo A, et al. COVID-19 pandemic: effects and evidence-based recommendations for otolaryngology and head and neck surgery practice. Head Neck Actions 2020;42(6):1259-67. doi: 10.1002/hed.26164

Brasil. Folha informativa sobre COVID-19. [Internet] 2020. [cited 2020 Nov 17]. Available from: https://www.paho.org/pt/covid19

Patroclo CB. Cefaleia e Covid: Qual a relação. Portal Pubmed (2020). [cited 2020 Dec 6]. Available from: https://pebmed.com.br/cefaleia-e-covid-19-qual-a-relacao-#

Greve JMD, Brech GC, Quintana M, Soares ALS, Alonso AC. Impacts of COVID-19 on the immune, neuromuscular, and musculoskeletal systems and rehabilitation. Rev Bras Med Esporte 2020;26(4):285-8. doi: 10.1590/1517-869220202604esp002

Silva RMV, Sousa AVC. Fase crônica da Covid-19: desafios do fisioterapeuta diante das disfunções musculoesqueléticas. Fisioterapia em Movimento (online) 2020;33:e0033002. doi: 10.1590/1980-5918.033.ed02

Murad MH, Asi N, Alsawas M, Alahdab F. New evidence pyramid. BMJ J 2016;21(4):125-7. doi: 10.1136/ebmed-2016-110401

Disser NP, Micheli AJ, Schonk MM, Konnaris MA, Piacentini NA, Edon DL, et al. Musculoskeletal consequences of Covid-19. J Bone Joint Surg 2020;102(14):1197-1204. doi: 10.2106/JBJS.20.00847

Abildúa AMJ, Ramírez PMT, Zabaleta RM, Valls NA, Salvador MMA, Algarra CL, et al. Neurological complications in critical patients with Covid-19. Neurologia 2020;35:621. doi: 10.1016/j.nrleng.2020.07.012

Anand P, Slama MCC, Kaku M, Ong C, Cervantes-Arsanian AM, Zhou L, et al. Covid-19 in patients with myasthenia gravis. Muscle Nerve 2020;62(2):254-8. doi: 10.1002/mus.26918

Abedi M. Physiotherapy management of musculoskeletal disorders in coronavirus disease: case report. Journal Clinical Physiotherapy Research 2020;5(2):e15. doi: 10.22037/jcpr.v5i2.30528

Dalakas MC. Guillain-Barré syndrome: the first documented COVID-19 – triggered autoimmune neurologic disease: more to come witn myositis in the offing. Neurol Neuroimmunol Neuroinflamm 2020;7(5):781. doi: 10.1212/NXI.0000000000000781

Cabañes-Martínez LC, Villadóniga M, González-Rodríguez L, Araque L, Díaz-Cid A, Ruz-Carucuel I, et al Neuromuscular involvement in COVID-19 critically ill patients. Clin Neurophysiol 2020;131(12):2809-16. doi: 10.1016/j.clinph.2020.09.017

Chen TH, Hsu JH. Respiratory management for patients with neuromuscular disorders during the Covid-19 pandemic. Ther Adv Respir Dis 2020;14. doi: 10.1177/1753466620953789

Montmeat D, Gard C, Raux M, Constantin JM, Tilleul P. Shortage of sedatives and neuromuscular blockers during COVID-19 pandemic: The result of an overstocking procedure in French hospitals? Anaesthesia Critical Care & Pain Medicine 2020; 39(5):585-586. doi: 10.1016/j.accpm.2020.06.013

Guidon A., Amato AA. COVID-19 and neuromuscular disorders. Neurology 2020;92(22). doi: 10.1212/WNL.0000000000009566

Paliwal KP, Garg RK, Gupta A, Tejan N. Neuromuscular presentations in patients with Covid-19. Neurol sci. 2020; 41:3039-56. https://link.springer.com/article/10.1007/s10072-020-04708-8

Published

2021-07-15