The impact of COVID-19 on the elderly population with non-communicable chronic lung disease
DOI:
https://doi.org/10.33233/fb.v23i1.4916Keywords:
COVID-19; infection by SARS-CoV2; aged; chronic pulmonary obstructive disease; non-communicable diseasesAbstract
Introduction: Aging brings with it biological changes that affect individuals in a heterogeneous way. Most organ systems experience a reduction in their function, which may involve muscle strength, static and dynamic balance, and respiratory function. The impairment of basic cognitive functions interferes with the ability to adapt to stressors. With the emergence of pneumonia caused by Sars-CoV2, Covid-19, originated in China in December 2019, the significant implication of lung function in the elderly, especially those with chronic lung, was evidenced. Objective: To investigate and present scientific evidence on the clinical implications of Covid-19 in elderly individuals with chronic non-communicable lung disease. Methods: This is an integrative literature review carried out in November 2020. The databases searched were: CINAHL (Cumulative Index to Nursing and Allied Health Literature), EMBASE, SCOPUS, MEDLINE/Pubmed (via National Library of Medicine) and Web of Science. The descriptors indexed in Decs and their crosses “Covid-19”, “Sars-Cov2 infection”, “Aged”, “Chronic pulmonary obstructive disease” e “Non-communicable diseases” were used with the use of the Boolean operators AND and OR. Studies were selected that met the following eligibility criteria: a) original scientific texts on Covid-19 in elderly people with Chronic Non-Communicable Respiratory Diseases (NCD); b) articles with descriptors previously defined in the context of the article and c) original articles available for consultation in full. Results: Elderly people with comorbidities are more likely to develop a serious condition and complications during the course of infection with high mortality rates, symptoms and atypical tomographic alterations. Conclusion: The severe form of Covid-19 and the high mortality in the elderly can be attributed to high comorbidity, the prevalence of dementia and geriatric syndromes.
References
Shahid Z, Kalayanamitra R, McClafferty B, Kepko D, Ramgobin D, Patel R, et al. COVID-19 and older adults: what we know. J Am Geriatr Soc 2020;68(5):926-9. doi: 10.1111/jgs.16472
Guo YR, Cao QD, Hong ZS, Tan YY, Chen SD, Jin HJ, et al. The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak – an update on the status. Mil Med Res 2020;7(1):1-10. doi: 10.1186/s40779-020-00240-0
Brasil. Ministério da Saúde. Secretarias Estaduais de Saúde. COVID-19 no Brasil [Internet]. Brasília, DF: Ministério da Saúde; 2020. [cited 2021 Mar 18]. Available from: https://infoms.saude.gov.br/extensions/covid-19_html/covid-19_html.html
Gao S, Jiang F, Jin W, Shi Y, Yang L, Xia Y, et al. Risk factors influencing the prognosis of elderly patients infected with COVID-19: a clinical retrospective study in Wuhan, China. Aging (Albany NY) 2020;11:12(13):12504-16. doi: 10.18632/aging.103631
Wu C, Chen X, Cai Y, Xia J, Zhou X, Xu S, et al. Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 pneumonia in Wuhan, China. JAMA Intern Med 2020;180(7):934-43. doi: 10.1001/jamainternmed.2020.0994
Mueller AL, McNamara MS, Sinclair DA. Why does COVID-19 disproportionately affect older people? Aging (Albany NY) 2020;12(10):9959-81. doi: 10.18632/aging.103344
Mo X, Jian W, Su Z, Chen M, Peng H, Peng P, et al. Abnormal pulmonary function in COVID-19 patients at time of hospital discharge. Eur Respir J 2020;55(6):1-4. doi: 10.1183/13993003.01217-2020
Zhu W, Xie K, Lu H, Xu L, Zhou S, Fang S. Initial clinical features of suspected coronavirus disease 2019 in two emergency departments outside of Hubei, China. J Med Virol 2020;92(9):1525-32. doi: 10.1002/jmv.25763
Arentz M, Yim E, Klaff L, Lokhandwala S, Riedo FX, Chong M, et al. Characteristics and outcomes of 21 critically ill patients with COVID-19 in Washington State. JAMA 2020;323(16):1612-4. doi: 10.1001/jama.2020.4326
Kiekens C, Boldrini P, Andreoli A, Avesani R, Gamna F, Grandi M, et al. Rehabilitation and respiratory management in the acute and early post-acute phase. “Instant paper from the field” on rehabilitation answers to the COVID-19 emergency. Eur J Phys Rehabil Med 2020;56(3):323-6. doi: 10.23736/S1973-9087.20.06305-4
Guerra S, Carsin AE, Keidel D, Sunyer J, Leynaert B, Janson C, et al. Health-related quality of life and risk factors associated with spirometric restriction. Eur Respir J 2017;49(5):1-11. doi: 10.1183/13993003.02096-2016
Souza MT, Silva M, Carvalho R. Revisão integrativa: o que é e como fazer. Einstein (São Paulo) 2010;8(1Pt 1):102-6. doi: 10.1590/s1679-45082010rw1134
Costa LOP, Maher CG, Lopes AD, Noronha MA de, Costa LCM. Como escrever de forma transparente artigos científicos relevantes para a prática da Fisioterapia. Rev Bras Fisioter (São Carlos) 2011;15(4):267-71. doi: 10.1590/S1413-35552011005000009
Dang JZ, Zhu GY, Yang YJ, Zheng F. Clinical characteristics of coronavirus disease 2019 in patients aged 80 years and older. J Integr Med 2020;18(5):395-400. doi: 10.1016/j.joim.2020.07.002
Wang L, He W, Yu X, Hu D, Bao M, Liu H, et al. Coronavirus disease 2019 in elderly patients: characteristics and prognostic factors based on 4-week follow-up. J Infect 2020;80(6):639-45. doi: 10.1016/j.jinf.2020.03.019
Rui L, Sirui L, Xuebei D, Xujun Y, Yanggan W. Clinical observations in very elderly patients with COVID-19 in Wuhan. Geriatr Gerontol Int 2020;20(7):709-14. doi: 10.1111/ggi.13974
Li P, Chen L, Liu Z, Pan J, Zhou D, Wang H, et al. Clinical features and short-term outcomes of elderly patients with COVID-19. Int J Infect Dis 2020;97:245-50. doi: 10.1016/j.ijid.2020.05.107
Guo T, Shen Q, Guo W, He W, Li J, Zhang Y, et al. Clinical characteristics of elderly patients with COVID-19 in Hunan province, China: a multicenter, retrospective study. Gerontol 2020;66(5):467-75. https:/doi.org/10.1159/000508734
Lian J, Jin X, Hao S, Cai H, Zhang S, Zheng L, et al. Analysis of epidemiological and clinical features in older patients with coronavirus disease 2019 (COVID-19) outside Wuhan. Clin Infect Dis 2020;71(15):740-7. doi: 10.1093/cid/ciaa242
Azarpazhooh MR, Morovatdar N, Avan A, Phan TG, Divani AA, Yassi N, et al. COVID-19 pandemic and burden of non-communicable diseases: an ecological study on data of 185 countries. J Stroke Cerebrovasc Dis 2020;29(9):105089. doi: 10.1016/j.jstrokecerebrovasdis.2020.105089
Wyper GMA, Assunção RMA, Cuschieri S, Devleesschauwer B, Fletcher E, Haagsma JA, et al. Population vulnerability to COVID-19 in Europe: a burden of disease analysis. Arch Public Health 2020;78(47):1-8. doi: 10.1186/s13690-020-00433-y
Dai SP, Zhao X, Wu JH. Effects of comorbidities on the elderly patients with COVID-19: clinical characteristics of elderly patients infected with COVID-19 from Sichuan, China. J Nutr Health Aging 2020;25(1):18-24. doi: 10.1007/s12603-020-1486-1
Becerra-Muñoz VM, Núñez-Gil IJ, Eid CM, Aguado MG, Romero R, Huang J, et al. Clinical profile and predictors of in-hospital mortality among older patients hospitalised for COVID-19. Age Ageing 2020;50(2):326-34. doi: 10.1093/ageing/afaa258
Deutsche Welle Coronavírus expõe vulnerabilidade de idosos na Europa. Germany: DW; 2020 Mar 24 [Internet]. [cited 2022 Jan 2022] Available from: https://www.dw.com/pt-br/coronav%C3%ADrus-exp%C3%B5e-vulnerabilidade-de-idosos-na-europa/a-52897626
Karagiannidis C, Mostert C, Hentschker C, Voshaar T, Malzahn J, Schillinger G, et al. Case characteristics, resource use, and outcomes of 10 021 patients with COVID-19 admitted to 920 German hospitals: an observational study. Lancet Respir Med 2020;8(9):853-62. doi: 10.1016/S2213-2600(20)30316-7
Gold JAW, Wong KK, Szablewski CM, Patel PR, Rossow J, Sila J, et al. Characteristics and clinical outcomes of adult patients hospitalized with COVID-19 – Georgia, March 2020. MMWR 2020;69(18):545-50. doi: 10.15585/mmwr.mm6918e1
Wortham JM, Lee JT, Althomsons S, Latash J, Davidson A, Guerra K, et al. Characteristics of persons who died with COVID-19. MMWR 2020;69(28):923-29. doi: 10.15585/mmwr.mm6928e1
Haase N, Plovsing R, Christensen S, Poulsen LM, Brøchner AC, Rasmussen BS, et al. Characteristics, interventions, and longer-term outcomes of COVID-19 ICU patients in Denmark – a nationwide, observational study. Acta Anaesthesiol Scand 2021;65(1):68-75. doi: 10.1111/aas.13701
Palmieri L, Vanacore N, Donfrancesco C, Lo Noce C, Canevelli M, Punzo O, et al. Clinical characteristics of hospitalized individuals dying with COVID-19 by age group in Italy. J Gerontol A Biol Sci Med Sci 2020;75(9):1796-1800. doi: 10.1093/gerona/glaa146
Zou L, Dai L, Zhang Y, Fu W, Gao Y, Zhang Z, et al. Clinical characteristics and risk factors for disease severity and death in patients with coronavirus disease 2019 in Wuhan, China. Front Med 2020;7:532. doi: 10.3389/fmed.2020.00532
Shi Q, Zhang X, Jiang F, Zhang X, Hu N, Bimu C, et al. Clinical characteristics and risk factors for mortality of COVID-19 patients with diabetes in Wuhan, China: a two-center, retrospective study. Diabetes Care 2020;43(7):1382-91. doi: 10.2337/dc20-0598
Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA 20207;323(11):1061-9. doi: 10.1001/jama.2020.1585
Niquini RP, Lana RM, Pacheco AG, Cruz OG, Coelho FC, Carvalho LM, et al. SRAG por COVID-19 no Brasil: descrição e comparação de características demográficas e comorbidades com SRAG por influenza e com a população geral. [Description and comparison of demographic characteristics and comorbidities in SARI from COVID-19, SARI from influenza, and the Brazilian general population]. Cad Saúde Pública 2020;36(7):1-12. doi: 10.1590/0102-311x00149420
Navaratnarajah A, Jackson S. The physiology of ageing. Medicine 2017;45(1):6-10. doi: 10.1016/j.mpmed.2016.10.008
Mesquita AF, Silva EC, Eickemberg M, Roriz AKC, Barreto-Medeiros JM, Ramos LB. Factors associated with sarcopenia in institutionalized elderly. Nutr Hosp 2017;34(2): 345-51. doi: 10.20960/nh.427
Mijnarends DM, Koster A, Schols JM, Meijers JMGA, Halfens RJG, Gudnason V, et al. Physical activity and incidence of sarcopenia: the population-based AGES – Reykjavik Study. Age Ageing 2016;45(5):614-20. doi: 10.1093/ageing/afw090
Brandenberger C, Mühlfeld C. Mechanisms of lung aging. Cell Tissue Res 2016;367(3):469-80. doi: 10.1007/s00441-016-2511-x
Elliott JE, Greising SM, Mantilla CB, Sieck GC. Functional impact of sarcopenia in respiratory muscles. Respir Physiol Neurobiol 2016;226(1):137-46. doi: 10.1016/j.resp.2015.10.001
López-Otín C, Blasco MA, Partridge L, Serrano M, Kroemer G. The hallmarks of aging. Cell 2013;153(6):1194-1217. doi: 10.1016/j.cell.2013.05.039
Kennedy BK, Berger SL, Brunet A, Campisi J, Cuervo AM, Epel ES, et al. Geroscience: linking aging to chronic disease. Cell 2014;159(4):709-13. doi: 10.1016/j.cell.2014.10.039
Li G, Fan Y, Lai Y, Han T, Li Z, Zhou P, et al. Coronavirus infections and immune responses. J Med Virol 2020; 92(4):424-32. doi: 10.1002/jmv.25685
Cunha L, Perazzio S, Azzi J, Cravedi P, Riella L. Remodeling of the immune response with aging: immunosenescence and its potential impact on COVID-19 immune response. Front Immunol 2020;11:1748. doi: 10.3389/fimmu.2020.01748
Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 2020;395(10223):497-506. doi: 10.1016/S0140-6736(20)30183-5
Callender LA, Curran M, Bates SM, Mairesse M, Weigandt J, Betts CJ. The impact of pre-existing comorbidities and therapeutic interventions on COVID-19. Front Immunol 2020;11:1991. doi: 10.3389/fimmu.2020.01991
Global Burden of Disease Study 2013 Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease study 2013. Lancet 2015;386(9995):743-800. doi: 10.1016/S0140-6736(15)60692-4
Word Health Organization (WHO). COVID-19 and NCDs: Preliminary results: rapid assessment of service delivery for noncommunicable diseases during the COVID-19 pandemic [Internet]. WHO 2020 May 29 [cited 2021 Mar 3]. Available from: https://reliefweb.int/report/world/covid-19-and-ncds-preliminary-results-rapid-assessment-service-delivery-noncommunicable
Olloquequi J. COVID-19 susceptibility in chronic obstructive pulmonary disease. Eur J Clin Invest 2020;50:1-8. doi: 10.1111/eci.13382
Leão L, Ferreira V, Faustino A. O idoso e a pandemia do COVID-19: uma análise de artigos em jornais. Braz J Dev 2020;6(7):45123-42. https://doi.org/10.34117/bjdv6n7-218
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