Português Pulmonary function, fatigue and quality of life of pediatric oncologic patients

Authors

DOI:

https://doi.org/10.33233/fb.v24i3.5396

Keywords:

oncology, pediatrics, spirometry, quality of life, fatigue

Abstract

Objective: To evaluate the pulmonary function (PF), the fatigue and quality of life (QoL) of children and adolescents diagnosed with cancer and to compare the results among those who were in oncological treatment in hospitalization with those who keep in outpatient follow-up. Methods: Cross-sectional study including pediatric oncology patients (6-17 years). We evaluated PF with spirometry, fatigue, and QoL using the Quality of Life Pediatric Questionnaire. Results: Fifty patients were evaluated, 24 hospitalized for oncological treatment and 26 on outpatient follow-up (five in the chemotherapy maintenance phase and 15 on follow-up). PF presented alteration in 26% of patients, not occurring significant difference (p = 0.416) among inpatients (33.3%) and outpatients (19.2%), nor for fatigue variables. Inpatients did not present a difference in QoL in relation to outpatients (p = 0.309), but the parents perceived a worse QoL in hospitalized patients (p = 0.046). A moderate agreement (r = 0.669) was found among perceptions of the parents (score 67.65 ± 16.06) and patients (score 74.47 ± 15.42) in relation to QoL. In the analysis of fatigue, was not found concordance among the perceptions of parents and patients (r = 0.353), because they were perceived themselves better. Conclusion: Pediatric oncology patients did not present significant alterations in PF, fatigue and QoL, although when hospitalized for treatment, they presented worse QoL than those monitoring in the outpatient clinic in the perception of their parents.

Author Biographies

Giana Berleze Penna , UFCSPA

Programa de Pós-Graduação em Ciências da Reabilitação, Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), RS, Brasil

Luciane Dalcanale Moussalle, UFCSPA

Professora adjunta, Departamento de Fisioterapia, da Universidade Federal de Ciências da Saúde (UFCSPA), Porto Alegre, RS, Brasil

Bruna Kuhn, UFRGS

Fisioterapeuta, Mestre em Ciências Pneumológicas, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil

Fabri­cio Edler Macagnan, UFCSPA

Professor adjunto, Departamento de Fisioterapia, Universidade Federal de Ciencias da Saude de Porto Alegre (UFCSPA), RS, Brasil

Jéssica Knisspell de Oliveira, UFCSPA

Programa de Pós-Graduação em Ciências da Reabilitação, Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), RS, Brasil

Charise Alexandra Fonseca de Mesquita, UFCSPA

Universidade Federal de Ciências da Saúde de Porto Alegre, Hospital da Criança Santo Antônio – Complexo Hospitalar Santa Casa de Misericórdia de Porto Alegre, RS, Brasil

References

IARC, International Childhood Cancer Day: Much remains to be done to fight childhood cancer. Press Release N° 241, 2016

Instituto Nacional de Câncer (INCA). Coordenação de Prevenção e Vigilância de Câncer. Estimativas 2023: incidência de câncer no Brasil [online]. [citado 2023 Jan 21]. Disponível em: https://www.inca.gov.br/sites/ufu.sti.inca.local/files/media/document/estimativa-2023.pdf

Michalowsk MB, Lorea CF, Rech A, Santiago P, Lorenzoni M, Taniguchi A, et al. Diagnóstico precoce em oncologia pediátrica: uma urgência médica. Boletim Científico de Pediatria [Internet]. 2012[citado 2022 out 12];(1):1. Disponível em: https://www.sprs.com.br/sprs2013/bancoimg/131210152055bcped_12_01_04.pdf

Santos S, Crespo C, Canavarro MC. Intensidade do tratamento e qualidade de vida relacionada com a saúde no cancro pediátrico. Psychology, Community & Health [Internet]. 2014 [citado 2022 out 12];3(3):158-71. Disponível em:

http://hdl.handle.net/10316/30532

Rubira EA, Marcon SR, Belasco AGS. Sobrecarga e qualidade de vida de cuidadores de criança e adolescentes com câncer em tratamento quimioterápico. Acta Paul Enferm. 2012;25(4):567-73. doi: 10.1590/S0103-21002012005000020

Macêdo TMF, Campos TF, Mendes REF, França DC, Chaves GSS, Mendonça KMPP. Função pulmonar de crianças com leucemia aguda na fase de manutenção da quimioterapia. Rev Paul Pediatr. 2014;32(4):320-5. doi: 10.1016/j.rpped.2014.06.005

Efrati O, Toren A, Duskin H, Goldstein G, Jacobson JM, Churi C. Spirometry follow-up in young children with hemato-oncology diseases. Med Sci Monit [Internet]. 2010 [citado 2022 Oct 10];16(3):28-33. Disponível em: https://medscimonit.com/abstract/index/idArt/878448

Miller MR, Hankinson J, Brusasco V, Burgos F, Casaburi R, Coates A, et al. Standardisation of spirometry. Eur Resp J. 2005;26(2):319-38. doi: 10.1183/09031936.05.00034805

Quanjer PH, Stanojevic S, Cole TJ, Baur X, Hall GL, Culver BH, et al. Multiethnic reference values for spirometry for the 3–95-yr age range: the global lung function 2012 equations. Eur Respir J. 2012;40(6):1324-43. doi: 10.1183/09031936.00080312

Klatchoian DA, Len CA et al. Quality of life of children and adolescents from São Paulo: reliability and validity of the Brazilian version of the Pediatric Quality of Life InventoryTM version 4.0 Generic Core Scales. J Pediatr. 2008;(84)4. doi: 10.2223/JPED.1788

Efrati O, Toren A, Duskin H, Moses DM, Bielorai B et al. Pulmonary Function Studies in Children Treated by Chemoradiotherapy and Stem Cell Transplantation. Pediatr Blood Cancer. 2008;51:684-8. doi: 10.1002/pbc.21722

Figueiredo GPZ, Zandonade E, Amorim MHC, Figueiredo LZ, Binda LA. Perfil epidemiológico dos casos novos de câncer infanto-juvenil em hospital de referência no Espírito Santo, Brasil, de 1986 a 2010. Rev Bras Pesq Saúde [Internet]. 2015 [citado 2022 out 10];17(4):109-20. https://periodicos.ufes.br/rbps/article/view/14337

Bauer DFV, Ferrari RAP, Reis TB, Tacla MTGM. Crianças com câncer: caracterização das internações em um hospital escola público. Semina: Ciências Biológicas e da Saúde. 2015; 36(1):9-16. doi: 10.5433/1679-0367.2015v36n1Suplp9

Pedrosa AO, Filho RL, Santos FJL, Gomes RNS, Monte LRS, Portela NLC. Perfil clínico-epidemiológico de clientes pediátricos oncológicos atendidos em um hospital de referência do Piauí. Revista Interdisciplinar 2015;8(3):12-21.

INCA incidência 2017. Incidência, mortalidade e morbidade hospitalar por câncer em crianças, adolescentes e adultos jovens no brasil: informações dos registros de câncer e do sistema de mortalidade [Internet]. [citado 2022 Oct 12]. Available from: http://www1.inca.gov.br/wcm/incidencia/2017/

Oguz A, Tayfun T, Citak EC, Karadeniz C, Tatlicioglu T, Boyunaga O, Bora H. Long-term pulmonary function in survivors of childhood Hodgkin disease and Non-Hodgkin lymphoma. Pediatr Blood Cancer. 2007;49:699-703. doi: 10.1002/pbc.21175

Venkatramani R, Kamath S, Wong K, Olch AJ, Malvar J, Sposto R, et al. Pulmonary outcomes in patients with Hodgkin Lymphoma treated with involved field radiation. Pediatr Blood Cancer. 2014;61:1277-81. doi: 10.1002/pbc.24969

Stone A, Friedman DN, Vorgal S, Kushner BH, Wolden S, Modak S, et al. Long-term pulmonary outcomes in pediatric survivors of high-risk neuroblastoma. J Pediatr Hematol Oncol. 2017;39(7):547-54. doi: 10.1097/MPH.0000000000000883

Record E, Williamson R, Masker KW, Mertens AC, Meacham LR, Popler J. Analysis of risk factors for abnormal pulmonary function in pediatric cancer survivors. Pediatr Blood Cancer. 2016;63:1264-71. doi: 10.1002/pbc.25969

Weiner DJ, Maity A, Carlson CA, Ginsberg JP. Pulmonary function abnormalities in children treated with whole lung irradiation. Pediatr Blood Cancer. 2006;46:222-27. doi: 10.1002/pbc.20457

Armenian SH, Landier W, Francisco L, Herrera C, Mills G, Siyahian A, et al. Long-term pulmonary function in survivors of childhood cancer. J Clin Oncol. 2015;33:14. doi: 10.1200/JCO.2014.59.8318

Faulk KE, Sopfe JM, Campbell K, Liptzin DR, Liu AK, Franklin ARK, et al. Pulmonary toxicity in paediatric patients with relapsed or refractory Hodgkin lymphoma receiving brentuximab vedotin. Br J Haematol. 2018;183:251-6. doi: 10.1111/bjh.15586

Huang TT, Hudson MM, Stokes DC, Krasin MJ, Spunt SL, Ness KK. Pulmonary outcomes in survivors of childhood cancer. Chest. 2011;140,4. doi: 10.1378/chest.10-2133

Erickson JM, Beck SL, Christian BR, Dudley W et al. Fatigue, sleep-wake disturbances, and quality of life in adolescents receiving chemotherapy. J Pediatr Hematol Oncol. 2011;33(1). doi: 10.1097/MPH.0b013e3181f46a46

Lauren CD, Lauren D B, Schwartz LA. Fatigue in adolescents with cancer compared to healthy adolescents. Pediatr Blood Cancer. 2013;60(11):1902-7. doi: 10.1002/pbc.24706

Pogorzala M, Styczvnski J, Kurylak A. et al. Health-related quality of life among paediatric survivors of primary brain tumours and acute leukaemia. Qual Life Res. 2010;19(1):191-8. doi: 10.1007/s11136-009-9580-1

Batalha LMC, Fernandes AM, Campos C. Qualidade de vida em crianças com câncer: concordância entre crianças e pais. Esc Anna Nery. 2015;19(2):292-6.

Anu VK, Onta M, Joshi S. Health-related quality of life of Nepalese children with leukemia using pediatric quality of life inventory 4.0 Generic Core Scale. J Pediatr Oncol Nurs. 2017;0(0). doi: 10.1177/1043454217703593

Kamran C, Goldberg SI, Kuhlthau KA, Lawell MP, Weyman EA, Gallotto SL, et al. Quality of life in patients with proton-treated pediatric meduloblastoma: results of a prospective assessment with 5-year follow-up. Cancer. 2018;124(16):3390-400. doi: 10.1002/cncr.31575

Berleutz J, Prokop A, Rustler MA. Effects of a 6-month, group-based, therapeutic exercise program for childhood cancer outpatients on motor performance, level of activity, and quality of life. Pediatr Blood Cancer. 2016;63:127-32. doi: 10.1002/pbc.25640

Published

2023-06-25