Effectiveness and safety of the use of room air compared to 100% oxygen in neonates under cardiac arrest at birth
DOI:
https://doi.org/10.33233/fb.v24i6.5522Keywords:
heart arrest, cardiopulmonary resuscitation, infant, newborn, oxygenAbstract
Introduction: Cardiac arrest at birth represents a serious problem worldwide. The commonly recommended practice for resuscitation of asphyxiated newborns has been the use of 100% oxygen for assisted ventilation. However, there is increasing evidence that ambient air is as effective as 100% oxygen and that 100% oxygen can have adverse effects on respiratory physiology and cerebral circulation. Objective: To compare the effectiveness and safety of using room air versus 100% oxygen in the resuscitation of neonates with cardiac arrest at birth. Methods: For this purpose, we will perform a systematic review of randomized controlled trials (RCTs). We will register the study protocol in the Prospero Platform. We will include neonates of any gestational age, diagnosed with cardiac arrest or neonatal asphyxia. We will perform searches in the following databases: Medical Literature Analysis and Retrieval System Online (Medline) via Pubmed, Excerpta Medica dataBASE (Embase) via Elsevier, Cochrane Central Register of Controlled Trials (CENTRAL) via Cochrane Library, Latin American Literature and the Caribbean in Health Sciences (Lilacs) via the Virtual Health Library Portal, with no restrictions on language or year of publication. The selection of studies, data extraction, assessment of bias of included studies and assessment of certainty of evidence will be performed by two independent researchers. Expected Results: We expect to clarify the effectiveness and safety of using ambient air compared to 100% oxygen, to provide useful information for clinical decision-making, and to support future high-quality randomized clinical trials on the subject
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Copyright (c) 2023 Benedita Monique Almeida Freires, Elayne Carvalho Santos, Ingrid Nazaré Lourinho Alves, Fernanda Gabriella de Siqueira Barros Nogueira, Juliana Anezia Rodrigues do Amaral, Ana Carolina Pereira Nunes Pinto, Natália Camargo Rodrigues Iosimuta
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