A obesidade e a ação dos prebióticos, probióticos e simbióticos na microbiota intestinal
DOI:
https://doi.org/10.33233/nb.v16i4.1279Abstract
A crescente prevalência da obesidade e suas comorbidades apresenta-se como um dos principais problemas de saúde pública atualmente. O intestino é um órgão complexo que tem sido cada vez mais estudado na obesidade devido í sua capacidade para sinalizar vias envolvidas na fisiopatologia da doença. Objetivo: Esclarecer os principais efeitos de prebióticos e probióticos nas alterações metabólicas e da microbiota intestinal na obesidade. A microbiota intestinal pode ser modulada pela dieta e atuar no controle da ingestão alimentar interagindo com receptores e enzimas que interferem nas alterações metabólicas decorrentes da obesidade e na modulação da resposta inflamatória. Pesquisas com animais mostraram resultados positivos do uso de prebióticos e probióticos como coadjuvantes no tratamento da obesidade, contudo, os resultados com humanos ainda apresentam dados controversos. Portanto a implementação de tal estratégia provavelmente vai abrir o caminho para alimentação personalizada e/ou estratégias terapêuticas inteligentes (incluindo a manipulação da microbiota intestinal através da concepção de novos probióticos, prebióticos e simbióticos para reverter problemas causados pela obesidade.
Palavras-chave: prebioticos, probioticos, obesidade, microbiota intestinal.
References
World Health Organization (WHO). Obesity and overweight. Fact sheet no. 311. WHO Media Center. [citado 2016 ago 26]. DisponÃvel em: http://www.who.int/mediacentre/factsheets/fs311/en/.
ABESO - Associação Brasileira para Estudo da Obesidade. [citado 2016 ago 25]. DisponÃvel em: www.abeso.org.br/noticia/dia-nacional-de-prevencao-da-obesidade.
Pistelli GC, Costa CEM. Bactérias intestinais e obesidade. Revista Saúde e Pesquisa 2010;3(1):115-6.
Gerard P. Gut microbiota and obesity. Cell Mol Life Sci 2016;73(1):147-62.
Graham C, Mullen A, Whelan K. Obesity and the gastrointestinal microbiota: A review of associations and mechanisms. Nutr Rev 2015; 73:376-85.
Festi D, Schiumerini R, Eusebi LH, Marasco G, Taddia M, Colecchia A. Gut microbiota and metabolic syndrome. World J Gastroenterol 2014;20(43):16079-94.
Jumpertz RDS, Turnbaugh PJ, Trinidad C, Bogardus C, Gordon JI et al. Energy-balance studies reveal associations between gut microbes, caloric load and nutrient absorption in humans. Am J Clin Nutr 2011;94(1):58-65.
DiBaise JK, Zhang H, Crowell MD, Krajmalnik-Brown R, Decker GA, Rittmann BE. Gut microbiota and its possible relationship with obesity. Mayo Clin Proc 2008;83(4):460-9.
Petschow B, Doré J, Hibberd P, Dinan T, Reid G, Blaser M et al. Probiotics, prebiotics, and the microbiome: the science of translation. Ann N Y Acad Sci 2013;1306:1-17. doi: 10.1111/nyas.12303
Quigley EMM. Prebiotics and probiotics; modifying and mining the microbiota. Pharmacol Res 2010;61(3):2138.
Park DY, Ahn YT; Park SE, Huh CS, Yoo SR, Yu R, Sung MK, McGregor RA, Choi MS. Supplementation of Lactobacillus curvatus HY7601 and Lactobacillus plantarum KY1032 in diet-induced obese mice is associated with gut microbial changes and reduction in obesity. PLoS One 2013;8(3):e59470. doi: 10.1371/journal.pone.0059470
Rodrigues A. Microbiota intestinal e sua possÃvel relação com a obesidade. ABESO 2011;53(5).
Gerritsen J, Smidt H, Rijkers Ger T, de Vos WM. Intestinal microbiota in human health and disease: the impact of probiotics Genes Nutr 2011;6(3):209-40.
Fibali L, Henderson B, Sadiq ST, Donos N. Genetic dysbiosis: the role of microbial insults in chronic inflammatory diseases. J Oral Microbiol 2014;25(6).
Myles IA. Fast food fever: reviewing the impacts of the Western diet on immunity. Nutr J 2014;13:61.
Dasu MR, Ramirez S, Isseroff RR. Toll-like receptors and diabetes: a therapeutic perspective. Clin Sci (Lond) 2012;122(5):203-14.
Shen J, Obin MS, Zhao L. The gut microbiota, obesity and insulin resistance. Mol Aspects Med 2013;34(1):39-58.
Vijay-Kumar M, Aitken JD, Carvalho FA, Cullender TC, Mwangi S, Srinivasan S et al. Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5. Science 2010;328(5975):228-31.
Gibson GR, Roberfroid MB. Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. J Nutr 1995;125(6):1401-12.
Flesch AG, Poziomyck AK, Damin DC. The therapeutic use of symbiotics. Arq Bras Cir Dig 2014;27(3):206-9.
Denipote FG, Trindade EB, Burini RC. Probiotics and prebiotics in primary care for colon cancer. Arq Gastroenterol 2010;47(1):93-8.
Horvat M, Krebs B, Potrc S, Ivanecz A, Kompan L. Preoperative synbiotic bowel conditioning for elective colorectal surgery. Wien Klin Wochenschr 2010;122(Suppl2):26-30.
Organização Mundial de Gastroenterologia (OMGE). Guias práticos: probióticos e prebióticos; 2011. DisponÃvel em: http://www. worldgastroenterology.org/assets/export/userfiles/Probiotics_FINAL_pt_2012.pdf.
Hill C, Guarner F, Reid G, Gibson GR, Merenstein DJ, Pot B, Morelli L, Canani RB, Flint HJ, Salminen S, Calder PC, Sanders ME. The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nat Rev Gastroenterol Hepatol 2014;11(8):506-14. doi: 10.1038/nrgastro.2014.66.
Salminen S, Loveren H. Probiotics and prebiotics: health claim substantiation. Microb Ecol Health Dis 2012;23: 10.3402/mehd.v23i0.18568.
Hutkins RW, Krumbeck JA, Bindels LB, Cani PD, Fahey G Jr, Goh YJ, Hamaker B, Martens EC, Mills DA, Rastal RA, Vaughan E, Sanders ME. Prebiotics: why definitions matter. Curr Opin Biotechnol 2016.;37:1-7.
European Food Safety Authority. Reasoned opinion on the modification of the existing maximum residue levels (MRLs) for dazomet in several vegetables. EFSA Journal 2015;13(3):4049.
Mookiah S, Sieo CC, Ramasamy K, Abdullah N, Ho YW. Effects of dietary prebiotics, probiotic and synbiotics on performance, caecal bacterial populations and caecal fermentation concentrations of broiler chickens. J Sci Food Agric 2014;94(2):341-8.
Khaksar V, Golian A, Kermanshahi H. Immune response and ileal microflora in broilers fed wheat-based diet with or without enzyme Endofeed W and supplementation of thyme essential oil or probiotic PrimaLac. African Journal of Biotechnology 2012;11(81):14716-23.
Pedroso AA, Hurley-Bacon AL, Zedek AS, Kwan TW, Jordan APO, Avellaneda G, Hofacre CL, Oakley BB, Collett SR, Maurer JJ, Lee MD. Can probiotics improve the environmental microbiome and resistome of commercial poultry production? Int J Environ Res Public Health 2013;10(10):4534-59.
Abdelqader A, Irshaid R, Al-Fataftah AR. Effects of dietary probiotic inclusion on performance, eggshell quality, cecal microflora composition, and tibia traits of laying hens in the late phase of production. Trop Anim Health Prod 2013;45(4):1017-24.
Mountzouris K, Tsitrsikos P, Palamidi I, Arvaniti A, Mohnl M, Schatzmayr G, Fegeros K. Effects of probiotic inclusion levels in broiler nutrition on growth perfor-mance, nutrient digestibility, plasma immunoglobulins and cecal microflora composition. Poult Sci 2010;89(1):58-67.
Daskiran M, Onol AG, Cengiz O, Unsal H, Turkyilmaz S, Tatli O, Sevim O. Influence of dietary probiotic inclusion on growth performance, blood parameters, and intestinal microflora of male broiler chickens exposed to posthatch holding time. J Appl Poult Res 2012;21(3):612-22.
Rahman M, Mustari A, Salauddin M, Rahman M. Effects of probiotics and enzymes on growth performance and haematobiochemical parameters in broilers. Journal of the Bangladesh Agricultural University 2013;11(1):111-8.
Bai S, Wu A, Ding X, Lei Y, Bai J, Zhang K, Chio J. Effects of probiotic-supplemented diets on growth performance and intestinal immune characteristics of broiler chickens. Poult Sci 2013;92(3):663-70.
Hill C, Guarner F, Reid G, Gibson GR, Merenstein DJ, Pot B et al. Expert consensus document. The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nat Rev Gastroenterol Hepatol 2014;11:506-14.
Bindels LB, Neyrinck AM, Claus SP, Roy CI, Grangette C, Pot B, Martinez I, Walter JD, Cani P, Delzenne NM. Synbiotic approach restores intestinal homeostasis and prolongs survival in leukaemic mice with cachexia. ISME Journal 2016;10:1456-70.
Varavallo MA, Santos TT. A importância de probióticos para o controle e/ou reestruturação da microbiota intestinal. Revista Itpac 2011;4(1).
Verspreet J, Damen B, Broekaert WF, Verbeke K, Delcour JA, Courtin CM. A critical look at prebiotics within the dietary fiber concept. Annu Rev Food Sci Technol 2016;7:167-90.
FAO/WHO. Health and nutritional properties of probiotics in food including powder milk with live lactic acid bacteria. Food and Agriculture Organization of the United Nations; 2001 Acessado: 19/Abril/2017.
Brasil. Agência Nacional de Vigilância Sanitária (ANVISA). Alimentos. Comissões e Grupos de Trabalho. Comissão TecnocientÃfica de Assessoramento em Alimentos Funcionais e Novos Alimentos. Alimentos com Alegações de Propriedades Funcionais e ou de Saúde, Novos Alimentos/ Ingredientes, Substâncias Bioativas e Probióticos. [citado 2017 mar 14]. DisponÃvel em: http://www.anvisa.gov.br/alimentos/comissoes/tecno_lista_alega.htm.
SPED - Sociedade Portuguesa de Endoscopia Digestiva; 2009. [citado 2017 mar 16]. DisponÃvel em: www.sped.pt/index.php?option=com_k2
Aguilar LT, Esparza JRE, Fragoso LR. Effect of probiotic BIO-L6® on intestinal morphology, microbiota and serum cytokines in obese Zucker rats. FASEB J 2014;28(1):633-47.
Kadooka Y, Sato M, Imaizumi K, Ogawa A, Ikuyama K, Akai Y et al. Regulation of abdominal adiposity by probiotics (Lactobacillus gasseri SBT2055) in adults with obese tendencies in a randomized controlled trial. Eur J Clin Nutr 2010;64(6):636-43.
Everard A, Lazarevic V, Derrien M, Girard M, Muccioli GG, Muccioli GM et al. Responses of gut microbiota and glucose and lipid metabolism to prebiotics in genetic obese and diet-induced leptin-resistant mice. Diabetes 2011;60(11):2775-86.
Nguyen TD, Kang JH, Lee MS. Characterization of lactobacillus plantarum PH04, a potential probiotic bacterium with cholesterol-lowering effects. Int J Food Microbiol 2007;113:358-61.
Salaj R, Štofilová J, Šoltesová A, Hertelyová Z, Hijová E, Bertková I, Strojný L, Kružliak P, Bomba A. The effects of two Lactobacillus plantarum strains on rat lipid metabolism receiving a high fat diet. ScientificWorldJournal 2013: 135142.
