Association between frailty and peripheral arterial disease

Authors

DOI:

https://doi.org/10.33233/rbfe.v19i2.3891

Keywords:

peripheral arterial disease; cardiovascular disease; chronic disease; fragility

Abstract

Background: Frailty has been associated with lifestyle, chronic diseases, and genetic alterations and with high levels of proinflammatory proteins, justifying the relationship proposed by the emerging literature that seeks associations between frailty and cardiovascular diseases. Objective: To investigate clinical and sociodemographic factors associated with frailty, emphasizing the relationship with peripheral arterial disease. Methods: Medical records of 76 patients were analyzed, considering the results of the ankle-brachial index test, fragility, sociodemographic and clinical variables. After the descriptive analysis, differences between groups were tested by chi-square test, student’s t-test and Tukey's post hoc test, when they were appropriated. The value of p < 0.05 for statistically significant differences was considered. Results: The prevalence of frailty in the study sample was 22.3%, and 47.3% for pre-frail. Frailty was associated with female gender, hypertension, dyslipidemia and level of education. Changes in ankle-brachial index test were statistically associated with frailty. Conclusion: The results of this research show the necessary targeted efforts to prevent and treat frailty.

Author Biographies

Sérgio Ribeiro Barbosa, Faculdade de São Lourenço

Faculdade de São Lourenço, departamento de Educação Física, São Lourenço, MG, Brazil

Natália Rodrigues dos Reis, UFJF

Universidade Federal de Juiz de Fora, MG, Brasil

Henrique Novais Mansur, IF Sudeste MG

Instituto Federal do Sudeste de Minas Gerais, Departamento Acadêmico de Educação (DAE), Núcleo de Educação Física e Saúde, Rio Pomba, MG, Brazil

References

Longo DL, Kasper DL, Jameson JL, Fauci AS, Hauser SL, Loscalzo J. Medicina Interna de Harrison. Porto Alegre: AMGH; 2013.

Golomb BA, Dang TT, Criqui MH. Peripheral arterial disease: morbidity and mortality implications. Circulation 2006;114(7):688-99. doi: 10.1161/CIRCULATIONAHA.105.593442

Coelho TC. Risco cardiovascular, adesão ao tratamento medicamentoso anti-hipertensivo e Fragilidade em idosos hipertensos [Dissertação]. Campinas: Universidade Estadual de Campinas. Faculdade de Ciências Médicas; 2013.

Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci 2001;56(3):M146-M157. doi: 0.1093/gerona/56.3.m146

Chen X, Mao G, Leng SX. Frailty syndrome: an overview. Clin Interv Aging 2014;9:433. doi: 10.2147/CIA.S45300

Afilalo J. Frailty in patients with cardiovascular disease: why, when, and how to measure. Current Cardiovasc Risk Reports 2011;5(5):467.

Makdisse M, Pereira AC, Brasil DP, Borges JL, Coelho GLM, Krieger JE. Prevalence and risk factors associated with peripheral arterial disease in the Hearts of Brazil Project. Arq Bras Cardiol 2008;91(6):402-14. doi: 10.1590/S0066-782X2008001800008

Hiatt WR. Medical treatment of peripheral arterial disease and claudication. N Engl J Med 2001;344(21):608-1621. doi: 10.1056/NEJM200105243442108

Duarte Y, Nunes DP, Andrade FB, Corona LP, Brito TRP, Santos JLF, Lebrão ML. Fragilidade em idosos no município de São Paulo: prevalência e fatores associados. Rev Bras Epidemiol 2019;21. doi: 10.1590/1980-549720180021.supl.2

Manfredi G, Midão L, Paúl C, Cena C, Duarte M, Costa E. Prevalence of frailty status among the European elderly population: Findings from the Survey of Health, Aging and Retirement in Europe. Geriatr Gerontol Int 2019;19(8):723-9. doi: 10.1111/ggi.13689

Lang P, Michel J, Zekry D. Frailty syndrome: A transitional state in a dynamic process. Gerontology 2009;55(5):39-49. doi: 10.1159/000211949

Trevisan C, Veronese N, Maggi S, Baggio G, Toffanello ED, Zambon S et al. Factors influencing transitions between frailty states in elderly adults: The Progetto Veneto Anziani Longitudinal Study. J Am Geriatr Soc 2017;65(1):179-184. doi: 10.1111/jgs.14515

Xue Q, Qin MZ, Jia J, Liu JP, Wang Y. Association between frailty and the cardio-ankle vascular index. Clinical Intervention in Aging 2019;14:735. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487894/

Schaap LA, Pluijm SMF et al. Higher inflammatory marker levels in older persons: associations with 5-year change in muscle mass and muscle strength. J Gerontol A Biol Sci Med Sci 2009;64(11):1183-9.

Barzilay JI, Blaum C, Moore T, Xue QL, Hirsch CH, Walston JD, Fried LP. Insulin resistance and inflammation as precursors of frailty: the Cardiovascular Health Study. Arch Intern Med 2007;167(7):635-41. doi: 10.1001/archinte.167.7.635

Alvim RO. Impacto de marcadores genéticos no fenótipo de rigidez arterial em uma população geral [Tese]. São Paulo: Universidade de São Paulo; 2012.

Zaslavsky O, Cochrane BB, Thompson HJ, Woods NF, Herting JR, LaCroix A. Frailty: a review of the first decade of research. Biol Res Nurs 2013;15(4):422-32. doi: 10.1177/1099800412462866

Silva DK, Nahas MV. Prescrição de exercícios físicos para pessoas com doença vascular periférica. Rev Bras Ciênc Mov 2008;10(1):55-61.

Lima A, Ribeiro VM, Catelli JR, Roberto. Indicador de Alfabetismo Funcional–INAF: Estudo especial sobre alfabetismo e mundo do trabalho. São Paulo: Instituto Paulo Montenegro: Ação Educativa, 2016. [citado 2019 Jun 12]. Disponível em: http://acaoeducativa.org.br/wpcontent/uploads/2016/09/INAFEstudosEspeciais_2016_Letramento_e_Mundo_do_Trabalho.pdf

Silva ZPD, Ribeiro MCSDA, Barata RB, Almeida MFD. Perfil sociodemográfico e padrão de utilização dos serviços de saúde do Sistema Único de Saúde (SUS), 2003-2008. Ciênc Saúde Colet 2011;16:3807-16.

Myers V, Drory Y, Goldbourt U, Gerber Y. Multilevel socioeconomic status and incidence of frailty post myocardial infarction. Int J Cardiol 2014;170(3):338-43. doi: 10.1016/j.ijcard.2013.11.009

Wanaratna K, Muangpaisan W, Kuptniratsaikul V, Chalermsri C, Nuttamonwarakul A. Prevalence and Factors Associated with Frailty and Cognitive Frailty Among Community-Dwelling Elderly with Knee Osteoarthritis. J Community Health 2019;44(3):587-95. doi: 10.1007/s10900-018-00614-5

Buto MSS, Catai AM, Vassimon-Barroso V, Gois MO, Porta A, Takahashi AC. Baroreflex sensitivity in frailty syndrome. Braz J Med Biol Res 2019;52(4). doi: 10.1590/1414-431x20198079

Bastos-Barbosa RG, Ferriolli E, Coelho EB, Moriguti JC, Nobre F, Costa Lima NK. Association of frailty syndrome in the elderly with higher blood pressure and other cardiovascular risk factors. Am J Hypertens 2012;25(11):1156-61. doi: 10.1038/ajh.2012.99

Newman AB, Gottdiener JS, Mcburnie MA, Hirsch CH, Kop WJ, Tracy R et al. Associations of subclinical cardiovascular disease with frailty. J Gerontol A Biol Sci Med Sci 2001;56(3):M158-M166. doi: 10.1093/gerona/56.3.m158

Fattori A, Santimaria MR, Alves RMA, Guariento ME, Neri AL. Influence of blood pressure profile on frailty phenotype in community-dwelling elders in Brazil–FIBRA study. Arch Gerontol Geriatr 2013;56(2):343-9. doi: 10.1016/j.archger.2012.08.004

Benetos, A et al. Treatment with multiple blood pressure medications, achieved blood pressure, and mortality in older nursing home residents: the PARTAGE study. JAMA Intern Med 2015;175(6):989-95. doi: 10.1001/jamainternmed.2014.8012

Xavier HT, Izar MC, Faria Neto JR, Assad MH, Rocha VZ, Sposito AC et al. V Diretriz Brasileira de Dislipidemias e Prevenção da Aterosclerose. Arq Bras Cardiol 2013;101(4):1-20.

Landi F, Russo A, Cesari M, Pahor M, Bernabei R, Onder G. HDL-cholesterol and physical performance: results from the ageing and longevity study in the sirente geographic area (ilSIRENTE Study). Age Ageing 2007;36(5):514-20. doi: 10.1093/ageing/afm105

Chanti-Ketterl M, Gamaldo A, Andel R, Thorpe Junior RJ. The association between lipoproteins, disability, and physical function among older Costa Rican adults. J Aging Health 2018;30(5):758-77. doi: 10.1177/0898264317690866

Published

2021-10-18