Efeitos do exercício em indivíduos com doenças renais crônicas: um mapa de evidências

Revisão - número e225384 - publicado 20 de junho de 2023

Autores

DOI:

https://doi.org/10.33233/rbfex.v22i1.5384

Palavras-chave:

nefropatias, exercício físico, prática clínica baseada em evidências, revisão sistemática

Resumo

Introdução: A despeito do comprometimento da capacidade funcional e redução de qualidade de vida, pacientes com doença renal crônica (DRC) são extremamente inativos. Sendo assim, o exercício apresenta papel essencial no manejo da doença e tem sido fortemente recomendado, independentemente da severidade da doença. Mapear as principais evidências sobre a temática oportuniza a prática baseada em evidências. Objetivo: Sumarizar os efeitos de intervenções baseadas em exercícios físicos em pacientes com DRC a partir da elaboração de um mapa de evidências. Métodos: Após busca abrangente nas bases de dados, os estudos elegíveis foram analisados por duas revisoras. Os dados foram extraídos e plotados em uma matriz associando intervenções e desfechos. A síntese narrativa incluiu somente os achados relativos aos estudos de revisão publicados nos últimos cinco anos. O nível de confiança foi avaliado conforme recomendado. Resultados: Ao todo, 75 estudos de revisão publicados entre 2005 e 2022 foram incluídos no mapa, porém apenas 50 foram descritos na síntese narrativa. Encontramos 179 associações, principalmente positivas, a partir da análise da plotagem de 20 intervenções categorizadas em sete grupos e 27 desfechos em 13 grupos. Não foram reportados efeitos negativos, potencialmente negativos ou adversos, sugerindo que a prática de exercício é segura para pacientes com DRC. Conclusão: As evidências mapeadas apresentam, em sua maioria, alto nível de confiança, corroborando o papel da prescrição do exercício para pacientes com DRC como intervenção segura e com efeitos majoritariamente positivos para múltiplos desfechos, com destaque para aptidão física, desfechos clínicos, e qualidade de vida e bem-estar.

Biografia do Autor

Leticia Gimenes dos Santos de Moura, UNIFESP

Curso de especialização em Fisiologia do Exercício Aplicada à Clínica, Universidade Federal de São Paulo, Santos, SP, Brasil

Thatiane Lopes Valentim Di Paschoale Ostolin, UNIFESP

Laboratório de Epidemiologia e Movimento Humano, Universidade Federal de São Paulo, Santos, SP, Brasil

Referências

KDIGO 2020. Clinical practice guideline for diabetes management in chronic kidney disease. Kidney Int. [Internet]. 2020 [cited 22 Jul 22]. Available from: https://www.elsevier.com/books-and-journals/

Ammirati AL. Chronic kidney disease. Rev Assoc Med Bras. 2020;66(1):3-9. doi: 10.1590/1806-9282.66.S1.3

Brasil. Ministério da Saúde. Doenças renais crônicas. [Internet]. [cited 2022 Jul 22]. Available from: https://www.gov.br/saude/pt-br/assuntos/saude-de-a-a-z/d/drc

Brasil. Ministério da Saúde. 12/3: Dia mundial do rim. Biblioteca Virtual em Saúde MS [Internet]. [cited 2022 Jul 25]. Available from: https://bvsms.saude.gov.br/12-3-dia-mundial-do-rim/

Marinho AGBW, Penha AP, Silva MTS, Galvão TF. Prevalência de doença renal crônica em adultos no Brasil: revisão sistemática da literatura. Cad Saúde Coletiva. 2017;25(3):379-88. doi: 10.1590/1414-462X201700030134

Barcellos FC, Santos IS, Umpierre D, Bohlke M, Hallal PC. Effects of exercise in the whole spectrum of chronic kidney disease: a systematic review. Clin Kidney J. 2015;8(6):753. doi: 10.1093/ckj/sfv099

Almutary H, Bonner A, Douglas C. Symptom burden in chronic kidney disease: a review of recent literature. J Ren Care. [Internet]. 2013 [cited 2022 nov 9];39(3):140-50. Available from: https://onlinelibrary.wiley.com/doi/full/10.1111/j.1755-6686.2013.12022.x

Ibrahim AA, Althomali OW, Atyia MR, Hussein HM, Abdelbasset WK, Eldesoky MTM, et al. A systematic review of trials investigating the efficacy of exercise training for functional capacity and quality of life in chronic kidney disease patients. Int Urol Nephrol. 2022];54(2):289-98. doi: 10.1007/s11255-021-02917-4

Pedersen BK, Saltin B. Exercise as medicine - Evidence for prescribing exercise as therapy in 26 different chronic diseases. Scand J Med Sci Sports. 2015;25:1-72. doi: 10.1111/sms.12581

Wilkinson TJ, Shur NF, Smith AC. “Exercise as medicine” in chronic kidney disease. Scand J Med Sci Sports. 2016;26(8):985-8. doi: 10.1111/sms.12581

Heiwe S, Jacobson SH. Exercise training in adults with CKD: A systematic review and meta-analysis. Am J Kidney Dis. 2014;64(3):383-93. doi: 10.1053/j.ajkd.2014.03.020

Sheng K, Zhang P, Chen L, Cheng J, Wu C, Chen J. Intradialytic exercise in hemodialysis patients: A systematic review and meta-analysis. Am J Nephrol. 2014;40(5):478-90. doi: 10.1159/000368722

Heiwe S, Jacobson SH. Exercise training in adults with CKD: A systematic review and meta-analysis. Am J Kidney Dis. 2014;64(3):383-93. doi: 10.1053/j.ajkd.2014.03.020

Snilstveit B, Vojtkova M, Bhavsar A, Stevenson J, Gaarder M. Evidence & Gap Maps: A tool for promoting evidence informed policy and strategic research agendas. J Clin Epidemiol. 2016;79:120-9. doi: 10.1016/j.jclinepi.2016.05.015

COFFITO. Conselho Federal de Fisioterapia e Terapia Ocupacional Resolução No424, de 08 de julho de 2013.

Fundação Oswaldo Cruz. Sumário de Mapas de Evidências: metodologia e aplicação [Internet]. [cited 2022 Jul 23]; Available from: https://cursos.campusvirtual.fiocruz.br/local/meucampus/courseinfo.php?id=343

Shea BJ, Reeves BC, Wells G, Thuku M, Hamel C, Moran J, et al. AMSTAR 2: a critical appraisal tool for systematic reviews that include randomised or non-randomised studies of healthcare interventions, or both. BMJ. 2017;358:4008. doi: 10.1136/bmj.j4008http://www.bmj.com/

Haddaway NR, Macura B, Whaley P, Pullin AS. ROSES RepOrting standards for Systematic Evidence Syntheses: pro forma, flow-diagram and descriptive summary of the plan and conduct of environmental systematic reviews and systematic maps. Environ Evid. 2018;7:7. doi: 10.1186/s13750-018-0121-7

Lu Z, Xu Y, Song Y, Bíró I, Gu Y. A mixed comparisons of different intensities and types of physical exercise in patients with diseases related to oxidative stress: a systematic review and network meta-analysis. Front Physiol. 2021;12:700055. doi: 10.3389/fphys.2021.700055

Thangarasa T, Imtiaz R, Hiremath S, Zimmerman D. Physical activity in patients treated with peritoneal dialysis: a systematic review and meta-analysis. Can J Kidney Health Dis. 2018;5:1-13. doi: 10.1177/205435811877982

Chen JJ, Lee TH, Tu YK, Kuo G, Yang HY, Yen CL, et al. Pharmacological and nonpharmacological treatments for restless legs syndrome in end stage kidney disease: a systematic review and component network meta-analysis. Nephrol Dial Transplant [Internet] 2021 [cited 2022 Jul 23];Available from: https://pubmed.ncbi.nlm.nih.gov/34612498

Hu H, Liu X, Chau PH, Choi EPH. Effects of intradialytic exercise on health-related quality of life in patients undergoing maintenance haemodialysis: a systematic review and meta-analysis. Qual Life Res. 2022;31(7):1915-32. doi: 10.1007/s11136-021-03025-7

Villanego F, Naranjo J, Vigara LA, Cazorla JM, Montero ME, García T, et al. Impacto del ejercicio físico en pacientes con enfermedad renal crónica: revisión sistemática y metaanálisis. Nefrología. 2020;40(3):237-52. doi: 10.1016/j.nefro.2020.01.002

Hargrove N, el Tobgy N, Zhou O, Pinder M, Plant B, Askin N, et al. Effect of aerobic exercise on dialysis-related symptoms in individuals undergoing maintenance hemodialysis: a systematic review and meta-analysis of clinical trials. Clin J Am Soc Nephrol. 2021 [cited 2022 Jul 23];16(4):560-74. doi: 10.2215/CJN.15080920

Lu Y, Wang Y, Lu Q. Effects of exercise on muscle fitness in dialysis patients: a systematic review and meta-analysis. Am J Nephrol [Internet] 2019 [cited 2022 Jul 23];50(4):291-302. doi: 10.1159/000502635

Ferreira TL, Ribeiro HS, Ribeiro ALA, Bonini-Rocha AC, Lucena JMS, Oliveira PA, et al. Exercise interventions improve depression and anxiety in chronic kidney disease patients: a systematic review and meta-analysis. Int Urol Nephrol. [Internet] 2021 [cited 2022 Jul 23];53(5):925-33. Available from: https://pubmed.ncbi.nlm.nih.gov/32869171/

Wu L, Liu Y, Wu L, Yang J, Jiang T, Li M. Effects of exercise on markers of inflammation and indicators of nutrition in patients with chronic kidney disease: a systematic review and meta-analysis. Int Urol Nephrol. 2022;54(4):815-26. doi: 10.1007/s11255-021-02949-w

Nakamura K, Sasaki T, Yamamoto S, Hayashi H, Ako S, Tanaka Y. Effects of exercise on kidney and physical function in patients with non-dialysis chronic kidney disease: a systematic review and meta-analysis. Sci Rep. 2020;10(1):18195. doi: 10.1038/s41598-020-75405-x

Nantakool S, Rerkasem K, Reanpang T, Worraphan S, Prasannarong M. A systematic review with meta-analysis of the effects of arm exercise training programs on arteriovenous fistula maturation among people with chronic kidney disease. Hemodial Int. 2020;24(4):439-53. doi: 10.1111/hdi.12875Wu X, Yang L, Wang Y, Wang C, Hu R, Wu

Y. Effects of combined aerobic and resistance exercise on renal function in adult patients with chronic kidney disease: a systematic review and meta-analysis. Clin Rehabil. 2020 Jul;34(7):851-65. doi: 10.1177/0269215520924459

Yang L, Wu X, Wang Y, Wang C, Hu R, Wu Y. Effects of exercise training on proteinuria in adult patients with chronic kidney disease: A systematic review and meta-analysis. BMC Nephrol. 2020;21(1):172. doi: 10.1186/s12882-020-01816-7

Huang CW, Lee MJ, Wang LJ, Lee PT, Tu YK, Hsu CW, et al. Comparative efficacy and acceptability of treatments for restless legs syndrome in end-stage renal disease: a systematic review and network meta-analysis. Nephrol Dial Transplant. 2020;35(9):1609-18. doi: 10.1093/ndt/gfz097

Schardong J, Stein C, della Méa Plentz R. Neuromuscular electrical stimulation in chronic kidney failure: a systematic review and meta-analysis. Arch Phys Med Rehabil. 2020;101(4):700-11. doi: 10.1016/j.apmr.2019.11.008

Ferrari F, Helal L, Dipp T, Soares D, Soldatelli Â, Mills AL, et al. Intradialytic training in patients with end-stage renal disease: a systematic review and meta-analysis of randomized clinical trials assessing the effects of five different training interventions. J Nephrol. 2020;33(2):251-66. doi: 10.1007/s40620-019-00687-yAndrade FP, Rezende PS,

exercise on cardiopulmonary capacity in chronic kidney disease: systematic review and meta-analysis of randomized clinical trials. Sci Rep. 2019 Dec 5;9(1):18470. doi: 10.1038/s41598-019-54953-x

Huang M, Lv A, Wang J, Xu N, Ma G, Zhai Z, et al. Exercise training and outcomes in hemodialysis patients: systematic review and meta-analysis. Am J Nephrol. 2019;50(4):240-54. doi: 10.1159/000502447

Peng S, He J, Huang J, Lun L, Zeng J, Zeng S, et al. Self-management interventions for chronic kidney disease: A systematic review and meta-analysis. BMC Nephrol. 2019;20(1):1-13. doi: 10.1186/s12882-019-1309-y

Ferreira GD, Bohlke M, Correa CM, Dias EC, Orcy RB. Does intradialytic exercise improve removal of solutes by hemodialysis? a systematic review and meta-analysis. Arch Phys Med Rehabil. [Internet] 2019 [cited 2022 Jul 23];100(12):2371-80. doi: 10.1016/j.apmr.2019.02.009

Clarkson MJ, Bennett PN, Fraser SF, Warmington SA. Exercise interventions for improving objective physical function in patients with end-stage kidney disease on dialysis: A systematic review and meta-analysis. Am J Physiol Renal Physiol. 2019;316(5):F856–72. doi: 10.1152/ajprenal.00317.2018

Thompson S, Wiebe N, Padwal RS, Gyenes G, Headley SAE, Radhakrishnan J, et al. The effect of exercise on blood pressure in chronic kidney disease: A systematic review and meta-analysis of randomized controlled trials. PLoS One. 2019;14(2):e0211032. doi: 10.1371/journal.pone.0211032

Pu J, Jiang Z, Wu W, Li L, Zhang L, Li Y, et al. Efficacy and safety of intradialytic exercise in haemodialysis patients: a systematic review and meta-analysis. BMJ Open. 2019;9(1):e020633. doi: 10.1136/bmjopen-2017-020633

Salhab N, Karavetian M, Kooman J, Fiaccadori E, el Khoury CF. Effects of intradialytic aerobic exercise on hemodialysis patients: a systematic review and meta-analysis. J Nephrol. 2019;32(4):549-66. htts://doi.org/10.1007/s40620-018-00565-z

Scapini KB, Bohlke M, Moraes OA, Rodrigues CG, Inácio JF, Sbruzzi G, et al. Combined training is the most effective training modality to improve aerobic capacity and blood pressure control in people requiring haemodialysis for end-stage renal disease: systematic review and network meta-analysis. J Physiother. [Internet]. 2019;65(1):4-15. Disponível em: https://diretoriacientificaicfuc.org.br/wp-content/uploads/2021/07/Combined-training-is-the-most.pdf

Wyngaert K vanden, van Craenenbroeck AH, van Biesen W, Dhondt A, Tanghe A, van Ginckel A, et al. The effects of aerobic exercise on eGFR, blood pressure and VO2peak in patients with chronic kidney disease stages 3-4: A systematic review and meta-analysis. PLoS One. 2018;13(9):e0203662. htps://doi.org/0.1371/journal.pone.0203662

Young HML, March DS, Graham-Brown MPM, Jones AW, Curtis F, Grantham CS, et al. Effects of intradialytic cycling exercise on exercise capacity, quality of life, physical function and cardiovascular measures in adult haemodialysis patients: a systematic review and meta-analysis. Nephrology Dialysis Transplantation. [Internet] 2018 [cited 2022 Jul 23];33(8):1436-45. Available from: https://academic.oup.com/ndt/article/33/8/1436/4955890

Gomes Neto M, de Lacerda FFR, Lopes AA, Martinez BP, Saquetto MB. Intradialytic exercise training modalities on physical functioning and health-related quality of life in patients undergoing maintenance hemodialysis: systematic review and meta-analysis. Clin Rehabil. 2018;32(9):1189-202. doi: 10.1177/0269215518760380

Koch Nogueira PC, Santis Feltran L de, Camargo MF, Leão ER, Benninghoven JR, Gonçalves NZ, et al. Prevalência estimada da doença renal crônica terminal em crianças no Estado de São Paulo. Rev Assoc Med Bras. 2011;57(4):443-9. doi: 10.1590/S0104-42302011000400020

Zhang L, Wang Y, Xiong L, Luo Y, Huang Z, Yi B. Exercise therapy improves eGFR, and reduces blood pressure and BMI in non-dialysis CKD patients: Evidence from a meta-analysis. BMC Nephrol. 2019;20(1):1-12. doi: 10.1186/s12882-019-1586-5

Kelen de Aguiar LI, Ruscitto Prado III R, Gazzinelli AI, Carvalho Malta DI, Kelen de Aguiar Avenida Professor Alfredo L. Fatores associados à doença renal crônica: inquérito epidemiológico da Pesquisa Nacional de Saúde Factors associated with chronic kidney disease: epidemiological survey of the National Health Survey. Rev Bras Epidemiol. 2020;23. doi: 10.1590/1980-549720200044

Bernier-Jean A, Beruni NA, Bondonno NP, Williams G, Teixeira-Pinto A, Craig JC, et al. Exercise training for adults undergoing maintenance dialysis. Cochrane Database of Systematic Reviews. 2022;2022(1). doi: 10.1002/14651858.CD014653/full

Yamamoto R, Ito T, Nagasawa Y, Matsui K, Egawa M, Nanami M, et al. Efficacy of aerobic exercise on the cardiometabolic and renal outcomes in patients with chronic kidney disease: a systematic review of randomized controlled trials. J Nephrol 2021;34(1):155-64. doi: 10.1007/s40620-020-00865-3

Evangelidis N, Craig J, Bauman A, Manera K, Saglimbene V, Tong A. Lifestyle behaviour change for preventing the progression of chronic kidney disease: a systematic review. BMJ Open. 2019;9(10):e031625. doi: 10.1136/bmjopen-2019-031625

Cai Z, Yang Y, Zhang J. Effects of physical activity on the progression of diabetic nephropathy: a meta-analysis. Biosci Rep [Internet] 2021 [cited 2022 Jul 23];41(1). Available from: https://pubmed.ncbi.nlm.nih.gov/33289502/

Pei G, Tang Y, Tan L, Tan J, Ge L, Qin W. Aerobic exercise in adults with chronic kidney disease (CKD): a meta-analysis. International Urology and Nephrology. 2019;51(10):1787-95. doi: 10.1007/s11255-019-02234-x

Nicolodi GV, della Méa Plentz R, Righi NC, Stein C. Effects of aerobic exercise on patients with pre-dialysis chronic kidney disease: a systematic review of randomized controlled trials. doi: 101080/0963828820211900929

De A, Fernandes O, Alves Y, Sens S, Fonseca Junior PR, Calhes Franco De Moura R, et al. Impacto do uso do cicloergômetro na função respiratória, cardiovascular, capacidade aeróbica, funcional e qualidade de vida de pacientes com doença renal crônica em hemodiálise. Fisioter Bras. 2019;20(2):302-9. doi: 10.33233/fb.v20i2.2220

Ferraz FHRP, Rodrigues CIS, Gatto GC, Sá NM. Diferenças e desigualdades no acesso a terapia renal substitutiva nos países do BRICS. Cienc Saude Coletiva. 2017;22(7):2175-85. doi: 10.1590/1413-81232017227.00662017

Bakaloudi DR, Siargkas A, Poulia KA, Dounousi E, Chourdakis M. The effect of exercise on nutritional status and body composition in hemodialysis: a systematic review. Nutrients. 2020;12(10):3071. doi: 10.3390/nu12103071

Wen X, Wang Y, Zhao Q, Zhang H, Shi H, Wang M, et al. Nonpharmacological interventions for depressive symptoms in end-stage renal disease: a systematic review. West J Nurs Res. 2020;42(6):462-73. doi: 10.1177/0193945919857540

KDIGO 2021. Clinical practice guideline for the management of blood pressure in chronic kidney disease. Kidney Int. 2021;99(3S):S1-S87. doi: 10.1016/j.kint.2020.11.003

Esmailiyan M, Amerizadeh A, Vahdat S, Ghodsi M, Doewes RI, Sundram Y. Effect of different types of aerobic exercise on individuals with and without hypertension: an updated systematic review. Curr Probl Cardiol. 2021;48(3). doi: 10.1016/j.cpcardiol.2021.101034

Bündchen DC, Sousa H, Afreixo V, Frontini R, Ribeiro O, Figueiredo D, et al. Intradialytic exercise in end-stage renal disease: An umbrella review of systematic reviews and/or meta-analytical studies. Clin Rehabil. 2021;35(6):812-28. doi: 10.1177/0269215520986784

Valenzuela PL, Morales JS, Ruilope LM, Villa P, Santos-Lozano A, Lucia A. Intradialytic neuromuscular electrical stimulation improves functional capacity and muscle strength in people receiving haemodialysis: a systematic review. J Physiother. 2020;66(2):89-96. doi: 10.1016/j.jphys.2020.03.006

Afsar B, Siriopol D, Aslan G, Eren OC, Dagel T, Kilic U, et al. The impact of exercise on physical function, cardiovascular outcomes and quality of life in chronic kidney disease patients: a systematic review. Int Urol Nephrol. 2018;50(5):885-904. doi: 10.1007/s11255-018-1790-4

Kowal G, Rydzewski A. The effects of respiratory muscle training in chronic kidney disease patients on haemodialysis and peritoneal dialysis: a review. Medical Studies/Studia Medyczne. 2018;34(1):78-85. doi: 10.5114/ms.2018.74825

Natale P, Palmer SC, Ruospo M, Saglimbene VM, Rabindranath KS, Strippoli GFM. Psychosocial interventions for preventing and treating depression in dialysis patients. Cochrane Database Syst Rev. 2019;2019(12). doi: 10.1002/14651858.CD004542.pub3/full

Stevenson JK, Campbell ZC, Webster AC, Chow CK, Tong A, Craig JC, et al. eHealth interventions for people with chronic kidney disease. Cochrane Database Syst Rev. 2019;8(8). doi: 10.1002/14651858.CD012379.pub2

Yoo J, Ruppar T, Wilbur JE, Miller A, Westrick JC. Effects of home-based exercise on frailty in patients with end-stage renal disease: systematic review. Biol Res Nurs. 2022;24(1):48-63. doi: 10.1177/10998004211033031

Sheng K, Zhang P, Chen L, Cheng J, Wu C, Chen J. Intradialytic exercise in hemodialysis patients: a systematic review and meta-analysis. Am J Nephrol. [Internet] 2014 [cited 2022 Jul 23];40(5):478-90. doi: 10.1159/000368722

Murakami M, Aoki T, Sugiyama Y, Takeuchi M, Yui T, Koyama M, et al. Association between the transtheoretical model approach and sustained intradialytic pedaling exercise: A retrospective cohort study. Medicine. 2021;100(42):e27406. doi: 10.1097/MD.0000000000027406

Sanchez HM, Nascimento DMB, Castro K, Sanchez EGM, Melo Junior JP, Agostinho PLS. Benefícios da fisioterapia intradialítica na qualidade de vida, dor, edema e função respiratória de doentes renais crônicos. Fisioter Mov. 2018;31(0). doi: 10.1590/1980-5918.031.AO07

Brasil MS. Ministério da Saúde reajusta valores para tratamento de hemodiálise. [Internet]. [cited 2022 Nov 11]. Available from: https://www.gov.br/saude/pt-br/assuntos/noticias/2021-1/dezembro/ministerio-da-saude-reajusta-valores-para-tratamento-de-hemodialise

Alcalde PR, Kirsztajn GM. Gastos do Sistema Único de Saúde brasileiro com doença renal crônica. J Bras Nefrol. 2018;40(2). doi: 10.1590/2175-8239-JBN-3918

Publicado

2023-06-27